13 results found
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Ecology
    2. Epidemiology and Global Health

    Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

    Cara E Brook, Mike Boots ... Anieke van Leeuwen
    Bats' uniquely robust innate antiviral immune defenses select for faster transmitting viruses likely to generate extreme virulence upon spillover to secondary hosts with immune systems divergent from those of bat.
    1. Evolutionary Biology

    Multifactorial processes underlie parallel opsin loss in neotropical bats

    Alexa Sadier, Kalina TJ Davies ... Karen E Sears
    Parallel losses of short-wave light sensitivity in diverse bats occurred through independent changes at multiple steps in the conversion of genotype into functional phenotype, including pre-, during, and post-transcription.
    1. Computational and Systems Biology
    2. Ecology

    Place recognition using batlike sonar

    Dieter Vanderelst, Jan Steckel ... Marc W Holderied
    Echolocating bats may recognize locations in the environment (and navigate to them) by remembering the specific echo signature of those locations.
    1. Developmental Biology
    2. Evolutionary Biology

    Secondary ossification center induces and protects growth plate structure

    Meng Xie, Pavel Gol'din ... Andrei S Chagin
    The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.
    1. Neuroscience

    A connectomics-based taxonomy of mammals

    Laura E Suarez, Yossi Yovel ... Bratislav Misic
    Inter-species variations in connectome architecture across the mammalian phylogenetic spectrum recapitulate established taxonomic relationships defined by genetic, morphology, and behavioural differences, and are mainly driven by local changes in connectivity while hallmark global features tend to be conserved across species.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Updates to the zoonotic niche map of Ebola virus disease in Africa

    David M Pigott, Anoushka I Millear ... Simon I Hay
    Building on previous work (Pigott et al. 2014), estimates of areas of potential transmission of Ebola virus are revised and updated to provide a contemporary map for use by researchers and policymakers.
    1. Ecology
    2. Genetics and Genomics

    Education and Outreach: March Mammal Madness and the power of narrative in science outreach

    Katie Hinde, Carlos Eduardo G Amorim ... Christopher N Anderson
    Hypothetical battles between animals can be used to interest the general public in biology.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Recent evolutionary origin and localized diversity hotspots of mammalian coronaviruses

    Renan Maestri, Benoît Perez-Lamarque ... Hélène Morlon
    The common ancestor of extant mammalian coronaviruses originated recently in a bat species and their diversification occurred via preferential host switches rather than through codiversification with mammals.
    1. Microbiology and Infectious Disease

    Targeted genomic sequencing with probe capture for discovery and surveillance of coronaviruses in bats

    Kevin S Kuchinski, Kara D Loos ... Andrew DS Cameron
    Hybridization probe capture is useful for discovery and surveillance of novel coronaviruses, and its unique strengths complement existing methods like amplicon sequencing and deep metagenomic sequencing.

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