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    1. Immunology and Inflammation

    Ym1 protein crystals promote type 2 immunity

    Ines Heyndrickx, Kim Deswarte ... Bart N Lambrecht
    Protein crystallization is a rare event yet Ym1 crystals made from a chitinase-like protein are abundantly found in eosinophilic airway inflammation, where they promote type 2 immunity.
    1. Structural Biology and Molecular Biophysics

    Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

    Xiaomei Sun, Yuxin Ye ... Min Yao
    A structural and biochemical study reveals the molecular mechanism of the predator–prey associations of Aplysia kurodai and brown algae (akuBGL–phlorotannin/laminarin–EHEP system), which has high-potential applications in the biotechnology industry.
    1. Developmental Biology

    The proteolysis of ZP proteins is essential to control cell membrane structure and integrity of developing tracheal tubes in Drosophila

    Leonard Drees, Susi Schneider ... Matthias Behr
    Genetic analyses reveal the importance of dynamic protein processing at the apical cell membrane in response to forces damaging cell membranes during tube expansion in tubular organs.
    1. Microbiology and Infectious Disease

    Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

    Yuu Ishii, Hironori Ishii ... Shinichiro Maruyama
    Coral symbiotic alga is capable of degrading the own cell wall components by cellulase-related enzymes and releasing sugars as a simple and autonomous environmental response, even when the host-derived signals are not present.
    1. Microbiology and Infectious Disease

    Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolution

    Clair R Henthorn, Paul M Airs ... Mostafa Zamanian
    A single-cell gene expression atlas in a human parasitic nematode provides new insights into the distribution of anthelmintic targets and the origins of secretory molecules with diagnostic and therapeutic potential at the host–parasite interface.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Formation and three-dimensional architecture of Leishmania adhesion in the sand fly vector

    Ryuji Yanase, Flávia Moreira-Leite ... Jack D Sunter
    Using advanced volume electron microscopy, the ultrastructural and spatial organisation of Leishmania parasites strongly adhered to the gut of its sand fly vector was defined.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Lineage-specific differences and regulatory networks governing human chondrocyte development

    Daniel Richard, Steven Pregizer ... April M Craft
    The transcriptomic and epigenetic landscapes of developing human articular and growth plate cartilage reveal putative gene regulatory networks governing lineage commitment and tissue homeostasis.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Hypoxia-induced tracheal elasticity in vector beetle facilitates the loading of pinewood nematode

    Xuan Tang, Jiao Zhou ... Jianghua Sun
    An insect-transmissible plant pathogen, Bursaphelenchus xylophilus, uniquely excavates hypoxia to increase vector capacity via Muc91C-enhanced elasticity of tracheal tubes.
    1. Ecology
    2. Evolutionary Biology

    The deep-rooted origin of disulfide-rich spider venom toxins

    Naeem Yusuf Shaikh, Kartik Sunagar
    A remarkable case of the common evolutionary origin of a prominent spider venom component.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoFeatures for unsupervised exploration of cell types, tissues, and organs in volume electron microscopy

    Valentyna Zinchenko, Johannes Hugger ... Anna Kreshuk
    Unsupervised machine learning on the ultrastructure and shape of cells in volume electron microscopy yields a compact representation of cellular morphology that complements genetics-based cell type characterisation.