345 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

    Kira M Düsterwald et al.
    Mathematical models with experimental validation show that chloride transporters in the cell membrane, and not negatively charged impermeant molecules, generate the driving force used by GABA receptors to silence neurons.
    1. Neuroscience

    Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks

    Pascal Branchereau et al.
    Electrophysiological and simulation approaches show that a chloride-related longer relaxation of the inhibitory synaptic events partially compensates the early defect in the chloride homeostasis detected in fetal SOD spinal motoneurons.
    1. Neuroscience

    The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice

    Camille Dumon et al.
    Maternal obesity and excess of the adipocyte hormone leptin delays the emergence of synaptic inhibition in the developing brain mice.
    1. Genetics and Genomics
    2. Neuroscience

    Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. elegans

    Chanhyun Park et al.
    A ClC chloride channel protein allows neurons to interpret both temporal resolution and intensity of sensory input, which thereby contributes to an experience-dependent navigation behavior.
    1. Neuroscience

    Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential

    Stephanie C Gantz et al.
    Modifying membrane potential by an 'inhibitory' chloride conductance such as PSAM4-GlyR is inherently unstable because the normally low intracellular concentration of chloride is readily increased by influx of chloride.
    1. Developmental Biology

    Chloride channels regulate differentiation and barrier functions of the mammalian airway

    Mu He et al.
    The chloride channel Ano1/Tmem16a plays an essential and non-redundant role in the developing airway by inhibiting mucus cell hyperplasia and promoting proper immune function of the airway mucosal barrier.
    1. Biochemistry and Chemical Biology

    Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

    Dao-Lai Zhang et al.
    ADGRG2, an orphan GPCR, when coupled to CFTR via a regional Gq signaling on the apical membrane, acts to regulate efferent duct fluid reabsorption making it essential for male fertility.
    1. Ecology
    2. Genetics and Genomics

    Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

    Elin Sørhus et al.
    Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.
    1. Neuroscience

    The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs

    Ryan S Phillips et al.
    The effects of chloride homeostasis can explain diverse responses of basal ganglia output neurons to putatively inhibitory inputs and may tune these neurons' synchrony, oscillations and behavior in decision-making scenarios.
    1. Developmental Biology
    2. Neuroscience

    The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero

    Alexander GJ Skorput et al.
    Prenatal ethanol exposure results in aberrant tangential migration by altering NKCC1-mediated chloride homeostasis that can be mitigated by bumetanide.

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