57 results found
  1. June 2013

    Episode 1: June 2013

    In the first eLife podcast we hear about the origins of multicellularity, the Irish potato famine, hepatitis viruses, how fog affects the behaviour of car drivers, and the evolution of chromatin.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

    Oleg A Volkov et al.
    A catalytically dead paralog activates its cognate enzyme through an allosteric mechanism that combined structural and phylogenomic analysis indicates arose through acquisition of a dimerization domain, suggesting a general model for how complex allostery evolves.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation

    Travis J Eisemann et al.
    Whereas in a paradigmatic structure an SM protein chaperone clamps its client SNARE shut, a second structure demonstrates that an SM protein can also hold its SNARE open to promote assembly.
    1. Cell Biology
    2. Evolutionary Biology

    A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

    Omaya Dudin et al.
    Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.

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