52 results found
    1. Neuroscience

    Response repetition biases in human perceptual decisions are explained by activity decay in competitive attractor models

    James J Bonaiuto et al.
    Residual activity from previous trials in a biophysical decision network model causes biases in choice behavior such that a previous response is more likely to be repeated.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

    Camilo Barbosa et al.
    Evolutionary trade-offs enhance efficacy of antibiotic therapy by constraining bacterial adaptation in dependence of drug order and trade-off effect size.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling

    Doug K Tischer, Orion David Weiner
    Direct control of ligand binding half-life with light shows that lifetime strongly affects T cell signaling.
    1. Neuroscience

    Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

    Efrén Álvarez-Salvado et al.
    A high-throughput behavioral paradigm and computational modeling are used to decompose olfactory navigation in walking Drosophila melanogaster into a set of quantitative relationships between sensory input and motor output.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Phenotypic states become increasingly sensitive to perturbations near a bifurcation in a synthetic gene network

    Kevin Axelrod et al.
    Perturbations in the extracellular environment drive transitions from a highly stable memory state to an alternative phenotype in microorganisms.
    1. Structural Biology and Molecular Biophysics

    Regulatory switch at the cytoplasmic interface controls TRPV channel gating

    Lejla Zubcevic et al.
    C-terminal domain of thermoTRPV channels regulates channel gating at the cytoplasmic interface through a switch-like process.
    1. Neuroscience

    Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases

    Christine M Constantinople et al.
    The lateral orbitofrontal cortex promotes learning of abstract, task-specific biases, but not spatial ones.
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits

    Jodi A Hadden et al.
    All-atom molecular dynamics of the HBV capsid supports a role for structural asymmetry in biological function, reveals the potential for triangular pores to mediate cellular signaling, and indicates that capsid flexibility may limit resolution attainable by cryo-EM.
    1. Structural Biology and Molecular Biophysics

    Pre-transition effects mediate forces of assembly between transmembrane proteins

    Shachi Katira et al.
    A general mechanism for how powerful forces of assembly and protein mobility can emerge from phase transitions is established.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu et al.
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.

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