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    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

    Justyna B Startek et al.
    The activation and membrane localization of the broadly-tuned noxious chemosensory cation channel TRPA1 are regulated by direct interactions with cholesterol via CRAC motifs in transmembane segments 2 and 4.
    1. Cell Biology

    Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’

    Kevin C Courtney et al.
    We challenge a recent report that most of the cholesterol in the plasma membrane of mammalian cells is in the exofacial leaflet.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

    Pei-Ling Tsai et al.
    Lamin B receptor may provide a long-sought model system enabling unprecedented studies of protein quality control in the nuclear envelope of mammalian cells.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol

    Moutusi Manna et al.
    Atomistic simulations reveal how lipids can allosterically modulate membrane receptors.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

    Piyali Saha et al.
    Molecular analysis of cholesterol transport by NPC1 and NPC1L1 proteins reveals that cholesterol likely moves through these transporters, and ezetimibe blocks NPC1L1 by binding at the interface between multiple domains.
    1. Structural Biology and Molecular Biophysics

    Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin

    Carl Leung et al.
    Electron and atomic force microscopy show how bacterial toxins bind to a host membrane and assemble into arcs and rings, before undergoing a dramatic, concerted conformational change to insert into the membrane.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

    Michael Nguyen Trinh et al.
    The N-terminal domain of one NPC1 molecule can transfer its cholesterol to another NPC1 molecule lacking the N-terminal domain, suggesting that NPC1 forms multimers that transport cholesterol out of lysosomes.
    1. Developmental Biology
    2. Neuroscience

    Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

    Xin Zhou et al.
    Qki-Srebp2–mediated cholesterol biosynthesis is indispensable for myelinogenesis during early brain development.
    1. Biochemistry and Chemical Biology

    Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

    Rima S Chakrabarti et al.
    Accessible cholesterol levels in human red blood cells were found to be stable within individuals but vary >10-fold among individuals and this variability may contribute to differences in cholesterol trafficking among tissues.
    1. Cell Biology

    Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

    Li Zhang et al.
    The E3 ubiquitin ligase RNF145 is shown to contribute to crosstalk between the LXR and SREBP-2 pathways in the regulation of cholesterol homeostasis.