276 results found
    1. Computational and Systems Biology
    2. Neuroscience

    A cholinergic feedback circuit to regulate striatal population uncertainty and optimize reinforcement learning

    Nicholas T Franklin, Michael J Frank
    Computational modeling suggests that feedback between striatal cholinergic neurons and spiny neurons dynamically adjusts learning rates to optimize behavior in a variable world.
    1. Neuroscience

    Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons

    Samuel S Pappas et al.
    Conditional forebrain deletion of Tor1a generates a dystonia model with face, construct, and predictive validity, and demonstrates that striatal cholinergic interneurons are selectively vulnerable to loss of the dystonia protein torsinA.
    1. Neuroscience

    Corelease of acetylcholine and GABA from cholinergic forebrain neurons

    Arpiar Saunders et al.
    Neurons of the cholinergic system, which release the excitatory neurotransmitter acetycholine throughout the cortex, also release the inhibitory transmitter GABA, with potential implications for cognitive function.
    1. Cell Biology
    2. Neuroscience

    Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep

    Kun-Ming Ni et al.
    Cholinergic system play an important role in waking-to-sleep cycles and in sleep stabilization.
    1. Neuroscience

    A cell autonomous torsinA requirement for cholinergic neuron survival and motor control

    Samuel S Pappas et al.
    Conditional deletion of the DYT1 dystonia protein torsinA causes selective cell autonomous neurodegeneration of striatal and brainstem cholinergic neurons, and severe motor behavioral abnormalities.
    1. Neuroscience

    A cellular and regulatory map of the cholinergic nervous system of C. elegans

    Laura Pereira et al.
    Analyzing a map of all cholinergic neurons in the nematode C. elegans shows how these neurons are embedded in the C. elegans connectome and reveals the regulatory factors controlling their development.
    1. Neuroscience

    Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo

    Stefano Zucca et al.
    Optogenetics and in vivo recordings in mice reveal that pauses in cholinergic interneurons offer an alternative mechanism to inhibit subthreshold and suprathreshold events of spiny projection neurons.
    1. Neuroscience

    Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons

    Nao Chuhma et al.
    Dopamine neurons make novel glutamatergic connections to striatal cholinergic interneurons in the lateral dorsal striatum that are mediated by metabotropic glutamate receptors coupled to TrpC channels.
    1. Cell Biology
    2. Neuroscience

    Complete morphologies of basal forebrain cholinergic neurons in the mouse

    Hao Wu et al.
    The first complete 3D structures of mouse cholinergic neurons reveal the length and complexity of their axons, while calculations suggest that equivalent axons in the human brain are approximately than 100 meters long.
    1. Neuroscience

    Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions

    Jason R Klug et al.
    A brain-wide mapping of the direct inputs to striatal cholinergic and parvalbumin interneurons reveals connectivity differences and implies their distinct roles in regulating striatal function.

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