287 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

    Elias T Friman et al.
    OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo

    Gabriel N Aughey et al.
    A new method for in vivo cell-specific profiling of chromatin accessibility reveals local and global chromatin dynamics during the differentiation of neural and gut stem cell lineages.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromatin accessibility dynamics across C. elegans development and ageing

    Jürgen Jänes et al.
    Profiling chromatin accessibility and nuclear transcription across Caenorhabditis elegans development and ageing generated the first map of transcriptional regulatory elements and their activities across an animal's life.
    1. Chromosomes and Gene Expression

    Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers

    Timothy W R Kelso et al.
    ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, and its homolog ARID1B function to maintain chromatin accessibility and active histone modifications at enhancers.
    1. Genetics and Genomics
    2. Neuroscience

    Layer-specific chromatin accessibility landscapes reveal regulatory networks in adult mouse visual cortex

    Lucas T Gray et al.
    ATAC-seq, transcriptomics, and transcription factor motif searches collaborate to build a network that regulates gene expression in different cortical layers.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

    Chan-Wang Lio et al.
    TET methylcytosine oxidases cooperate with B lineage-specific transcription factors to promote immunoglobulin gene rearrangement by depositing 5hmC, facilitating DNA demethylation and increasing chromatin accessibility at enhancers.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Chromatin accessibility dynamics and single cell RNA-Seq reveal new regulators of regeneration in neural progenitors

    Anneke Dixie Kakebeen et al.
    Regenerating neural progenitors of the Xenopus tropicalis tail prioritize differentiation to motor neuron types earlier than proliferation, a decision partly regulated by the transcription factors Pbx3 and Meis1.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Simultaneous measurement of chromatin accessibility, DNA methylation, and nucleosome phasing in single cells

    Sebastian Pott
    A new method that measures multiple aspects of chromatin organization in single cells has a possible application to study regulatory processes in heterogeneous samples.
    1. Neuroscience

    Genome-wide identification of neuronal activity-regulated genes in Drosophila

    Xiao Chen et al.
    Activity-regulated genes in Drosophila neurons differ from the well-characterized situation in mammals, and these genes provided a strategy to construct reporters for monitoring neuronal activity in fly brains.

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