142 results found
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo

    Gabriel N Aughey et al.
    A new method for in vivo cell-specific profiling of chromatin accessibility reveals local and global chromatin dynamics during the differentiation of neural and gut stem cell lineages.
    1. Chromosomes and Gene Expression

    Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers

    Timothy W R Kelso et al.
    ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, and its homolog ARID1B function to maintain chromatin accessibility and active histone modifications at enhancers.
    1. Genetics and Genomics
    2. Neuroscience

    Layer-specific chromatin accessibility landscapes reveal regulatory networks in adult mouse visual cortex

    Lucas T Gray et al.
    ATAC-seq, transcriptomics, and transcription factor motif searches collaborate to build a network that regulates gene expression in different cortical layers.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

    Chan-Wang Lio et al.
    TET methylcytosine oxidases cooperate with B lineage-specific transcription factors to promote immunoglobulin gene rearrangement by depositing 5hmC, facilitating DNA demethylation and increasing chromatin accessibility at enhancers.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Simultaneous measurement of chromatin accessibility, DNA methylation, and nucleosome phasing in single cells

    Sebastian Pott
    A new method that measures multiple aspects of chromatin organization in single cells has a possible application to study regulatory processes in heterogeneous samples.
    1. Neuroscience

    Genome-wide identification of neuronal activity-regulated genes in Drosophila

    Xiao Chen et al.
    Activity-regulated genes in Drosophila neurons differ from the well-characterized situation in mammals, and these genes provided a strategy to construct reporters for monitoring neuronal activity in fly brains.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

    Hamish W King, Robert J Klose
    The chromatin remodeller BRG1 is recruited to pluripotency-associated gene regulatory elements by the pioneer transcription factor OCT4 to support further transcription factor binding and gene regulation.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

    Max A Horlbeck et al.
    Integrated modeling of sgRNA positioning, chromatin accessibility, and sequence features enables accurate prediction of effective target sites for CRISPR-mediated transcriptional modulation and design of highly active libraries for genome-scale genetic screens.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

    Nicholas T Hogan et al.
    An integrative genome-wide approach supports a direct and collaborative role of ETS and AP-1 transcription factors in maintaining endothelial cell-specific and anti-inflammatory gene expression programs.

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