263 results found
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
    1. Cell Biology
    2. Medicine

    Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

    Jin Rong Ow et al.
    Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
    1. Developmental Biology
    2. Genetics and Genomics

    Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice

    Mohamed Mahgoub et al.
    The meiotic recombination landscape in vertebrates was re-engineered via the co-evolution of a dual histone H3K4/H3K36 methylation 'writer' PRDM9 and its 'reader' ZCWPW1 that facilitates efficient double strand break repair.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

    Alexandre Giraud-Gatineau et al.
    The anti-tuberculosis drug bedaquiline reprograms human macrophages into potent bactericidal phagocytes, which are able to control bacterial infection.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones

    Dion Giovannone et al.
    Cartilage cells transition through a proliferative intermediate to give rise to bone and marrow fat cells in long bones.
    1. Chromosomes and Gene Expression

    Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth

    Zheng Kuang et al.
    General stress response factors Msn2 and Msn4 activate glycolytic genes and promote acetyl-CoA accumulation to stimulate growth and proliferation of yeast cells under a nutrient-limiting condition, suggesting the unexpected interrelationship between carbohydrate metabolism and stress response.
    1. Neuroscience

    DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

    Eva On-Chai Lau et al.
    DIAPH3 safeguards integrity of microtubule cytoskeleton during division of neural progenitor cells.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors

    John Frederick Beckmann et al.
    Genetic and proteomic screening with Wolbachia's CidB enzyme reveal the mechanisms and targets of cytoplasmic incompatibility (CI).
    1. Cell Biology

    Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast

    Grant A King et al.
    A meiotic nuclear remodeling event mediates cellular rejuvenation through elimination of senescence factors.
    1. Immunology and Inflammation

    Reversible promoter methylation determines fluctuating expression of acute phase proteins

    Shi-Chao Zhang et al.
    DNA methylation status can be exploited to finely and reversibly tune the expression of highly inducible genes with CpG-poor promoters in response to environmental cues.

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