294 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

    Wahid A Mulla et al.
    Genetic analyses reveal that purely quantitative changes in the relative copy number of chromosomes can be sufficient to disrupt the epigenetic mechanisms that define the cells' differentiated state.
    1. Biochemistry and Chemical Biology

    Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex

    Mingxuan Wu et al.
    Biochemical approaches reveal that an epigenetic histone deacetylase complex called CoREST is slow to deacetylate histone H3 lysine-14 in nucleosomes, and this inhibits demethylation of histone H3 lysine-4 by the CoREST complex.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

    Jan J Zylicz et al.
    Silencing of gene regulatory elements by modifications of DNA-bound proteins promotes the progression of early mouse development.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of human polycomb repressive complex 2

    Claudio Ciferri et al.
    Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes

    Roberto Bonasio et al.
    The Polycomb group protein SCML2 contributes to the assembly and gene silencing function of Polycomb Repressive Complex 1 (PRC1) and requires an RNA-binding region to reach chromatin targets.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent

    Shanshan Ai et al.
    During heart maturation, embryonic ectoderm development as a chromatin remodeler triggers transcriptional silencing, while H3K27me3 is a passenger that is not sufficient for gene silencing.
    1. Developmental Biology
    2. Evolutionary Biology

    Multicellularity: The evolution of gene regulation

    Veronica Hinman, Gregory Cary
    The gene regulation mechanisms necessary for the development of complex multicellular animals have been found in sponges.
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    1. Chromosomes and Gene Expression
    2. Plant Biology

    Plant-virus Interactions: Caught in a TrAP

    Delfina A Ré, Pablo A Manavella
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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Mitosis: Checkpoint proteins come under scrutiny

    Maria Mora-Santos, Jonathan BA Millar
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