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    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

    William F Richter et al.
    FLT3-ITD/STAT5A signaling is more sensitive to Dot1L inhibition than the canonical MLL-fusion activated drivers of leukemogenesis, providing a potential therapeutic avenue for one of the most frequent lesions in leukemia.
    1. Microbiology and Infectious Disease

    KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

    Rajnish Kumar Singh et al.
    KSHV nullifies hypoxic restriction of DNA replication.
    1. Developmental Biology
    2. Immunology and Inflammation

    Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

    Xia Liu et al.
    Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control checkpoint for thymocyte β-slection.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat et al.
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

    Ryo Miyamoto et al.
    HOXA9 is a transcriptional maintenance factor for anti-apoptotic genes that accelerate MYC-driven leukemia.
    1. Cancer Biology
    2. Developmental Biology

    E2F/Dp inactivation in fat body cells triggers systemic metabolic changes

    Maria Paula Zappia et al.
    The E2F/Dp transcription factors, which are key cell cycle regulators, can also mediate the regulation of carbohydrate metabolism in larva by controlling both systemic trehalose homeostasis and fat storage.
    1. Physics of Living Systems

    Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila

    Myron Barber Child VI et al.
    Biophysical modeling and quantitative live-cell imaging converge to show that the century-old puzzle of somatic homolog pairing in Drosophila operates via a button model.
    1. Immunology and Inflammation

    Pioneer neutrophils release chromatin within in vivo swarms

    Hannah M Isles et al.
    Neutrophil swarms form around a single endogenous pioneer neutrophil in vivo, mediated by DNA release from pioneer neutrophils.
    1. Developmental Biology
    2. Genetics and Genomics

    Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans

    Maria C Ow et al.
    Somatic aging and germline RNAi pathways promote inheritance of ancestral starvation memory through reallocation of fat storage in Caenorhabditis elegans.