The crystal structure of human Holliday junction resolvase GEN1 in complex with DNA reveals a conserved chromodomain as an additional DNA-anchoring point that opens new perspectives for enzyme regulation.

Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.

CBP/EP300 bromodomain inhibitors have a therapeutic application in oncology via targeting the IRF4 transcriptional program, a clinically validated network critical for multiple myeloma cell viability.

Yeast bromodomain-containing factors Bdf1/2 offer insights into the biological role of the BET family of transcriptional regulators, which is a promising target in cancer therapy.

Editors' Summary: This Replication Study has reproduced important parts of the original paper.

Suv39h1 chromodomain possesses nucleic acid-binding activity and this activity is coupled with its H3K9 methylation recognition in assembling heterochromatin.

SUV39H1 histone methyltransferase directly binds chromosome associated RNA to promote constitutive heterochromatin formation.

NMR spectroscopy, dCypher assays, and CUT&RUN demonstrate that occlusion of the histone tails in the nucleosome context alters histone PTM specificity for a tandem of reader domains.