1,295 results found
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

    Floris Foijer et al.
    Chromosomal instability through spindle assembly checkpoint alleviation facilitates malignant transformation of hepatocytes and T-cells in vivo, resulting in cancers with recurrent karyotypes.
    1. Cell Biology

    Centrosome age regulates kinetochore–microtubule stability and biases chromosome mis-segregation

    Ivana Gasic et al.
    The presence of cenexin at the old centrosome imposes a functional asymmetry on the mitotic spindle that impacts chromosome alignment and segregation.
    1. Chromosomes and Gene Expression

    The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability

    Lamia Wahba et al.
    When a protein involved in DNA repair malfunctions, it can anneal RNA molecules to DNA molecules, creating hybrids that increase the frequency of mutations in the DNA.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae

    Wei Zhang et al.
    E3 ubiquitin ligase Bre1-induced H2B monoubiquitination is epigenetically important for recruiting replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins to establish sister chromatid cohesion.
    1. Chromosomes and Gene Expression

    Catastrophic chromosomal restructuring during genome elimination in plants

    Ek Han Tan et al.
    Complex chromosomal rearrangements similar to those described in cancer and developmental syndromes occur in plants during postzygotic genome elimination, a centromeric-derived incompatibility.
    1. Developmental Biology

    Prolonged ovarian storage of mature Drosophila oocytes dramatically increases meiotic spindle instability

    Ethan J Greenblatt et al.
    Meiotic chromosome segregation in mature Drosophila oocytes is sensitive to prolonged quiescence, suggesting that human oocyte instability may result from storage of mature rather than primordial oocytes and be modifiable.
    1. Developmental Biology
    2. Genetics and Genomics

    Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

    Daniel Andergassen et al.
    Allele-specific expression due to genetic differences, X-chromosome inactivation or genomic imprinting, varies dynamically throughout development, and may be explained by allele-specific differences in stability or the actions of tissue-specific enhancers.

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