436 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Metagenomic chromosome conformation capture (meta3C) unveils the diversity of chromosome organization in microorganisms

    Martial Marbouty, Axel Cournac ... Romain Koszul
    A technique called meta3C provides an elegant and integrated approach to metagenomic analysis by allowing the de novo assembly, scaffolding and 3D characterization of unknown genomes from a complex mix of species
    1. Microbiology and Infectious Disease

    Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection

    Kinjal Majumder, Juexin Wang ... David J Pintel
    Development of a generally adaptable conformational capture assay for use in-trans identifies the specific direct interaction sites between the parvovirus minute virus of mice and the cellular genome during infection as sites of cellular DNA damage.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A combination of transcription factors mediates inducible interchromosomal contacts

    Seungsoo Kim, Maitreya J Dunham, Jay Shendure
    A pooled mutational scanning approach for 3D chromosome conformation reveals how multiple transcription factors can jointly specify condition-specific genome conformations.
    1. Chromosomes and Gene Expression

    Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

    Daan Noordermeer, Marion Leleu ... Denis Duboule
    Hox genes are activated sequentially and, at the same time, undergo a transition from an inactive to an active chromatin compartment, most likely to prevent posterior genes being activated too early.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The dynamic three-dimensional organization of the diploid yeast genome

    Seungsoo Kim, Ivan Liachko ... Maitreya J Dunham
    Yeast homologous chromosomes exhibit condition-specific mitotic pairing at both global and local scales.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres

    Krishnendu Guin, Yao Chen ... Kaustuv Sanyal
    Proximity and homology guided inter-chromosomal translocations drive karyotype evolution.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    OpenNucleome for high-resolution nuclear structural and dynamical modeling

    Zhuohan Lao, Kartik D Kamat ... Bin Zhang
    An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Single-molecule observation of DNA compaction by meiotic protein SYCP3

    Johanna L Syrjänen, Iddo Heller ... Luca Pellegrini
    Building on previous work (Syrjänen, Pellegrini, & Davies, 2014), it is shown that SYCP3 contributes to the architecture of meiotic chromosomes through local bridging interactions that result in large-scale compaction of the chromosome axis.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Competitive binding of MatP and topoisomerase IV to the MukB hinge domain

    Gemma LM Fisher, Jani R Bolla ... David J Sherratt
    Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.
    1. Chromosomes and Gene Expression

    CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

    Ryo Kariyazono, Takashi Osanai
    cyAbrB2, the global transcriptional factor conserved in cyanobacteria, is the nucleoid-associated protein, which is the first report in cyanobacteria.

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