501 results found
    1. Developmental Biology

    Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

    Eva Lana-Elola et al.
    A panel of seven new mouse strains with chromosomal duplications is used to identify a minimal genetic region required in three copies to cause congenital heart defects typical of human Down syndrome.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Selection of chromosomal DNA libraries using a multiplex CRISPR system

    Owen W Ryan et al.
    An optimized CRISPR-Cas9 system enables multiplexed genome engineering for evolving biomolecules and pathways from chromosomally integrated DNA libraries.
    1. Genetics and Genomics

    A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21

    Yasuhiro Kazuki et al.
    TcMAC21 is an appropriate “next gen” mouse model for DS research, and provides a proof of concept of using artificial chromosomes to generate non-mosaic humanized animal models of chromosome disorders.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

    Dongming Li et al.
    The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

    Mitsuhiro Endoh et al.
    PCGF6 links sequence specific target recognition by the MAX/MGA transcription factor complex to PRC1 (polycomb repressive complex 1) -dependent transcriptional silencing of germ cell-specific genes in mouse pluripotent stem cells.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis

    Jasmine C Wong et al.
    Immature hematopoietic cells from mice with a large segmental deletion found in human myeloid malignancies exhibit cardinal features of myelodysplastic syndrome.
    1. Genetics and Genomics

    RNA-programmed genome editing in human cells

    Martin Jinek et al.
    A bacterial protein can be programmed with short RNA molecules to stimulate genome editing at specific sites in human cells.
    1. Microbiology and Infectious Disease

    Dominant Vibrio cholerae phage exhibits lysis inhibition sensitive to disruption by a defensive phage satellite

    Stephanie G Hays, Kimberley D Seed
    Genetic and molecular analyses identify and characterize an evolutionary battle over lysis timing wherein a bacteriophage delays lysis through lysis inhibition while a defensive phage satellite accelerates lysis.
    1. Microbiology and Infectious Disease

    Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

    Noémie Matthey et al.
    Whole-genome sequencing reveals the remarkable extent of horizontally moving genetic material in naturally competent Vibrio cholerae after a prey-killing DNA acquisition process.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

    Amy R Strom et al.
    Micromanipulation experiments demonstrate that HP1α strengthens interphase and mitotic chromosome mechanics and maintains nuclear shape by chromatin crosslinking, separate from histone methylation.

Refine your results by:

Type
Research categories