2,125 results found
    1. Chromosomes and Gene Expression

    Exploring chromosomal structural heterogeneity across multiple cell lines

    Ryan R Cheng et al.
    Chromosomal structural ensembles are fluid yet are cell-type-specific, despite apparent disorder, appropriate collective variables uncover evidence of structural transitions associated with gene activity and cell differentiation.
    1. Chromosomes and Gene Expression

    Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes

    Oliver Crawley et al.
    By specifically antagonizing binding of complexes carrying COH-3/4 kleisins, WAPL-1 regulates chromosome structure and cohesion throughout meiotic prophase.
    1. Chromosomes and Gene Expression

    Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis

    Darpan Medhi et al.
    Different homologous recombination pathways are dominant in different regions of meiotic chromosomes, indicating that chromosome structure influences recombination biochemistry.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular model for the role of SYCP3 in meiotic chromosome organisation

    Johanna Liinamaria Syrjänen et al.
    A structural and biochemical study of human SYCP3 provides the first molecular model for the three-dimensional organisation that is imposed upon chromosomal DNA during meiosis and is essential for genetic exchange and fertility.
    1. Cell Biology

    Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation

    Ewa Piskadlo et al.
    Condensin I maintains chromosome organization throughout metaphase by preventing erroneous topoisomerase II-dependent sister chromatid re-entanglements.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    A conserved filamentous assembly underlies the structure of the meiotic chromosome axis

    Alan MV West et al.
    Meiotic chromosome axis 'core' proteins from fungi, plants, and mammals form a conserved filament architecture, and use a common mechanism to recruit HORMAD proteins for meiotic recombination control.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo

    Michael R Stadler et al.
    Fruit fly chromosomes are divided into discrete structural domains by regions of decompacted chromatin, suggesting a novel model for the formation of a known class of genetic elements.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending

    Aleksandra Bebel et al.
    DNA-bound crystal structures of an essential Xer site-specific recombinase from the bacterium Helicobacter pylori reveal how large conformational changes initiate the untangling of chromosomes upon cell division.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Global genome diversity of the Leishmania donovani complex

    Susanne U Franssen et al.
    Genomic data for the parasites that cause visceral leishmaniasis provides the first global picture of the diversity and evolution of the pathogen and the epidemiology of this fatal tropical disease.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans

    Pille Hallast et al.
    In addition to its academic merits, characterizing the genetic determinants of male (in)fertility and identifying clinically actionable genetic variants can lead to improved diagnosis or even treatment of such conditions.

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