181 results found
    1. Immunology and Inflammation
    2. Neuroscience

    Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

    Carolyn M Walsh et al.
    Neutrophils are essential for itch in a mouse model of atopic dermatitis, and promote the transition from acute to chronic itch via induction of CXCL10/CXCR3 signaling.
    1. Neuroscience

    MRGPRX4 is a bile acid receptor for human cholestatic itch

    Huasheng Yu et al.
    Bile acid and it's receptor MRGPRX4, but not TGR5, is one of the ligand-receptor pairs for chronic itch in patients with liver diseases.
    1. Immunology and Inflammation
    2. Neuroscience

    Autoimmunity: Bringing on the itch

    Daniel A Waizman et al.
    Neutrophils are the first immune cells that enter the skin and cause itch in atopic dermatitis.
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    1. Neuroscience

    Predicting non-linear dynamics by stable local learning in a recurrent spiking neural network

    Aditya Gilra, Wulfram Gerstner
    Recurrent neuronal networks learn to predict movement in a self-supervised way using biologically plausible learning rules.
    1. Neuroscience

    Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa

    Paul A Nakamura et al.
    Regulating rod gene expression with a small molecule ligand for the orphan nuclear receptor Nr2e3 rescues photoreceptors from degeneration in a mouse model of retinitis pigmentosa.
    1. Medicine

    Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical

    Elisabeth Gludovacz et al.
    Because heparin-binding motif mutations of human diamine oxidase (hDAO) block cellular uptake and strongly decrease clearance in vivo, modified recombinant hDAO might be a good candidate for the treatment of symptoms induced by excessive endogenous histamine release.
    1. Developmental Biology
    2. Neuroscience
    Pond snail illustration

    The Natural History of Model Organisms: The unlimited potential of the great pond snail, Lymnaea stagnalis

    István Fodor et al.
    The great pond snail is a multipurpose model organism and a contemporary choice for addressing a wide range of biological questions, problems and phenomena in the laboratory and the field.
    1. Ecology
    2. Neuroscience

    Range-dependent flexibility in the acoustic field of view of echolocating porpoises (Phocoena phocoena)

    Danuta M Wisniewska et al.
    Harbor porpoises dynamically control biosonar field of view as they track and capture prey, focusing the beam through deformations to the melon.
    1. Cell Biology
    2. Medicine

    Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

    Jin Rong Ow et al.
    Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
    1. Neuroscience

    Curvature domains in V4 of macaque monkey

    Jia Ming Hu et al.
    There is a systematic functional organization for curvature representation in area V4 where specific curvatures are encoded by unique values (modules) from the set of systematically represented values.

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