In mouse cardiomyocytes, (lymph)angiogenic growth factors are induced during early hypoxia by a translational mechanism involving a new IRES trans-acting factor, vasohibin-1.

The discovery that opioid neuropeptide neuronal signaling controls feeding behavior in a genetically tractable invertebrate model may help unravel the mechanisms of appetite control in humans.

Perforin-2 deficiency is lethal upon infection with pathogenic bacteria despite the presence of other bactericidal effectors.

Newly developed, highly active CRISPR interference single guide RNA libraries and effectors together enable high-quality genetic screens across cell models.

Targeted SOCS3 null mice reveal that maturation of cortical bone comprises both pore closure and accumulation of high density bone, requiring local suppression of gp130-STAT3 in osteocytes and subsequent osteoclastogenesis.

An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.

A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.

The hepatic endocannabinoid/CB₁R system controls the soluble leptin receptor’s expression and/or subsequent release by Trib3-induced regulation of C/EBP homologous protein levels in hepatocytes to affect leptin signaling in the liver.

The health benefits of caloric restriction, including decreasing body fat and blood glucose, differ between males and females and this difference depends on the age at which caloric restriction begins.