735 results found
    1. Neuroscience

    HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress

    Peng Zhong et al.
    HCN2 channels in the ventral tegmental area play an important role in the pathophysiology of chronic mild stress-induced behavioral deficits.
    1. Neuroscience

    Social dominance mediates behavioral adaptation to chronic stress in a sex-specific manner

    Stoyo Karamihalev et al.
    Social dominance has opposing effects on behavior following stress in male vs. female mice indicating an important role in sex differences in the stress response.
    1. Cell Biology

    CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

    Adi Drori et al.
    The hepatic endocannabinoid/CB1R system controls the soluble leptin receptor’s expression and/or subsequent release by Trib3-induced regulation of C/EBP homologous protein levels in hepatocytes to affect leptin signaling in the liver.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the Drosophila testis

    Salvador C Herrera, Erika A Bach
    JNK pathway activity induces spermatogonial dedifferentiation under challenging conditions to maintain the germline stem cell pool and to endow it with potentially fitter cells that have increased proliferation.
    1. Neuroscience

    Social Status: Modulating chronic stress

    Debra A Bangasser, Evelyn Ordoñes Sanchez
    Social rank differentially influences how male and female mice respond to chronic stress.
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    1. Cell Biology
    2. Neuroscience

    Pregnancy-associated plasma protein-aa regulates endoplasmic reticulum–mitochondria associations

    Mroj Alassaf, Mary C Halloran
    An extracellular modulator of IGF1 signaling, Pappaa, regulates endoplasmic reticulum–mitochondria connections, which are critical for metabolic homeostasis and hair cell survival.
    1. Neuroscience

    Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

    Özgür Genç et al.
    Forward genetic screens define a novel genetic landscape by which diverse, unrelated autism risk genes may converge to commonly affect the robustness of synaptic transmission.
    1. Computational and Systems Biology
    2. Neuroscience

    Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

    Amin Haghani et al.
    Transcriptome analysis of mouse brain revealed that the APOE4 allele and sex can alter air pollution neurotoxicity in adults.
    1. Epidemiology and Global Health
    2. Medicine

    Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh

    Audrie Lin et al.
    In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.
    1. Cell Biology

    The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

    Rolf M Schmidt et al.
    Endoplasmic reticulum stress in yeast activates not only the UPR but also Rpn4, promoting the clearance of misfolded proteins from the cytosol as part of a modular cross-compartment stress response.

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