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    1. Genetics and Genomics

    DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

    Hilda Tateossian, Amy Southern ... Steve DM Brown
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Streamlining segmentation of cryo-electron tomography datasets with Ais

    Mart GF Last, Leoni Abendstein ... Thomas H Sharp
    The software package Ais simplifies automated segmentation in cryo-electron tomography, enabling users to segment, detect particles, and visualize data in a streamlined and accessible workflow.
    1. Cancer Biology
    2. Cell Biology

    Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

    Zijing Wang, Bihan Xia ... Jilin Yang
    The inhibition of colorectal cancer (CRC) proliferation, migration, and invasion is attributed to BEST4, which exhibits epistasis over Hes4 in the downregulation of Twist1 and consequent suppression of epithelial-to-mesenchymal transition in CRC.
    1. Developmental Biology

    CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility

    Bingbing Wu, Chenghong Long ... Chao Liu
    CCDC113 is a key structural hub for sperm axoneme and head-tail coupling apparatus (HTCA) stability, with defects leading to male infertility through disruption of sperm flagellar and HTCA integrity.
    1. Cell Biology
    2. Developmental Biology

    Ciliary length regulation by intraflagellar transport in zebrafish

    Yi Sun, Zhe Chen ... Chengtian Zhao
    The speed of intraflagellar transport, influenced by particle size, shows a positive correlation with ciliary length in zebrafish.
    Version of Record
    Short Report
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    A cryo-electron tomography study of ciliary rootlet organization

    Chris van Hoorn, Andrew P Carter
    Cryo-electron tomography uncovers the flexible, filamentous architecture of mouse ciliary rootlets and their regular cross-striations with extensive membrane connections.
    1. Developmental Biology

    The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy

    Pooja Popli, Arin K Oestreich ... Ramakrishna Kommagani
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy

    Meet K Patel, Warlen Piedade, Jakub K Famulski
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

    Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology

    Reorganization of the flagellum scaffolding induces a sperm standstill during fertilization

    Martina Jabloñski, Guillermina M Luque ... Mariano G Buffone
    The double helix actin network surrounding the mitochondrial sheath of the sperm midpiece undergoes structural changes prior to the motility cessation during sperm-egg fusion.
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