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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

    Mark E Lush et al.
    Several support cell populations balance progenitor maintenance with differentiation in zebrafish lateral line sensory organs.
    1. Developmental Biology
    2. Evolutionary Biology

    Domestic chickens activate a piRNA defense against avian leukosis virus

    Yu Huining Sun et al.
    To protect the germ line genome, chickens acquire new small RNA-based immune defense in response to recently endogenized retroviruses by turning a truncated provirus into a weapon.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Fusion surface structure, function, and dynamics of gamete fusogen HAP2

    Juan Feng et al.
    Structure, dynamics, and mutation of a gamete fusion protein and comparisons to viral homologues suggest that after trimerization the domain bearing the membrane-inserting fusion loops can pivot with respect to the trimer 3-fold axis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication

    Shannon Burns et al.
    Visualization of yeast spindle pole proteins using a new microscopy method shows that assembly into the nuclear membrane occurs at the same time as duplication.
    1. Stem Cells and Regenerative Medicine

    Neural stem cells induce the formation of their physical niche during organogenesis

    Ali Seleit et al.
    A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.
    1. Neuroscience

    The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision

    Frans Vinberg et al.
    Molecular, genetic, and functional analysis is used to show that the olfactory Na+/Ca2+, K+ exchanger NCKX4 is expressed in cone photoreceptors and is critical for the wide operating range and high temporal resolution of cone-mediated vision.
    1. Cell Biology

    IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium

    Jenna L Wingfield et al.
    Multimegadalton intraflagellar transport (IFT) trains assemble by sequential recruitment of IFT subcomplexes from the cell body to the ciliary basal bodies and tubulin, the main IFT cargo, is loaded briefly before trains depart.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

    Kacper B Rogala et al.
    SAS-5 forms oligomers, through a trimeric coiled coil and novel dimeric domain, that are necessary for centriolar localisation of SAS-5 and for centriole duplication.
    1. Cell Biology

    A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

    Lori Clay et al.
    Sphingolipids govern the compartmentalization of yeast cells through the assembly of lateral diffusion barriers in ER membranes.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans

    David B Doroquez et al.
    The three-dimensional structures of 50 sensory cilia present in the head of the adult C. elegans hermaphrodite have been reconstructed to provide a foundation for investigations into the mechanisms by which the diversity of cilia structures is generated and how this structural diversity is related to specific sensory neuron functions.