126 results found
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

    Christopher N Rudzitis, Monika Lakk ... David Križaj
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Genetics and Genomics

    DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

    Hilda Tateossian, Amy Southern ... Steve DM Brown
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Developmental Biology

    Ciliary length regulation by intraflagellar transport in zebrafish

    Yi Sun, Zhe Chen ... Chengtian Zhao
    The speed of intraflagellar transport, influenced by particle size, shows a positive correlation with ciliary length in zebrafish.
    Version of Record
    Short Report
    • Valuable
    • Solid
    1. Developmental Biology

    Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy

    Meet K Patel, Warlen Piedade, Jakub K Famulski
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

    Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH-signaling in dorsal and ventral forebrain

    María Pedraza, Valentina Grampa ... Justine Masson
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction

    Morgane Djebar, Isabelle Anselme ... Christine Vesque
    Brain ventricular astrogliosis and neuroinflammation precede scoliosis onset in the zebrafish rpgrip1l ciliary mutant and anti-inflammatory treatment drastically reduces scoliosis while correcting urotensin related peptide level is ineffective.
    1. Neuroscience

    Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons

    Besma Brahmia, Yahaira Naaldijk ... Sabine Hilfiker
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

    Tristan A Bell, Bridget E Luce ... Luke H Chao
    Prominin 1 and Tweety Homology 1, two proteins that regulate membrane shape in neural and neuroepithelial cells, have shared evolutionary history and both cause cells to secrete extracellular vesicles.
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