126 results found
    1. Neuroscience

    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

    Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology
    2. Genetics and Genomics

    An atlas of cell types in the mouse epididymis and vas deferens

    Vera D Rinaldi, Elisa Donnard ... Oliver J Rando
    A systematic survey of the epididymis identifies the cell types involved in post-testicular maturation of sperm.
    1. Developmental Biology

    Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy

    Meet K Patel, Warlen Piedade, Jakub K Famulski
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology

    Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain

    Sweta Parab, Rachael E Quick, Ryota L Matsuoka
    Identification of a developmental mechanism critical for the generation of brain vessel heterogeneity.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

    Breane G Budaitis, Shashank Jariwala ... Kristen J Verhey
    Force generation by kinesin motor proteins requires formation of both a 2-stranded cover-neck bundle and an asparagine-based latch for transport of membrane-bound cargoes in cells.
    1. Cell Biology
    2. Developmental Biology

    Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumen

    Maria Danielle Sallee, Melissa A Pickett, Jessica L Feldman
    During intestinal development, apical PAR complex proteins keep apical domains and junctions continuous between cells as they divide and elongate, and ultimately build a continuous functional tube.
    1. Neuroscience

    A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

    June K Corrigan, Deepti Ramachandran ... Alexander S Banks
    The metabolic rate of mice is disproportionately affected by the site of experimentation, affecting the phenotypic interpretation of genetically modified strains.
    1. Neuroscience

    Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

    Zhong L Hua, Philip M Smallwood, Jeremy Nathans
    The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.
    1. Cell Biology
    2. Physics of Living Systems

    KymoButler, a deep learning software for automated kymograph analysis

    Maximilian AH Jakobs, Andrea Dimitracopoulos, Kristian Franze
    KymoButler is a machine learning approach towards the reliable, quick, and fully automated analysis of the dynamics of fluorescently labelled particles in living cells.
    1. Cell Biology
    2. Physics of Living Systems

    Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair

    Nicholas Mikolajewicz, Elizabeth A Zimmermann ... Svetlana V Komarova
    Bone cells exposed to physiological forces release ATP through repairable membrane injury, generating an intercellular signal that conveys the destructive potential of forces and the adaptive capacity of endangered cells.

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