182 results found
    1. Biophysics and Structural Biology
    2. Cell Biology

    Intraflagellar Transport: Trainspotting in a cilium

    Dhivya Kumar, Stephen M King
    A new imaging technique sheds light on how cilia regulate their length and growth.
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    1. Biophysics and Structural Biology
    2. Cell Biology

    Dynamics of the IFT machinery at the ciliary tip

    Alexander Chien et al.
    During intraflagellar transport (IFT), kinesin-II dissociates from IFT trains at the flagellar tip and its diffusion in flagella serves as a negative feedback mechanism that facilitates flagellar length control in Chlamydomonas.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Flagellar Beating: Row with the flow

    Benjamin M Friedrich, Ingmar H Riedel-Kruse
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  1. Living Science: In numbers we trust?

    Eve Marder
    Scientists go to great lengths to ensure that data are collected and analysed properly, so why do they apply different standards to data about the number of times research papers have been cited and viewed?
    1. Biophysics and Structural Biology
    2. Cell Biology

    Ion Channels: Signaling the differences between cilia

    Polina Lishko, Yuriy Kirichok
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    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Physical limits of flow sensing in the left-right organizer

    Rita R Ferreira et al.
    Large-scale in vivo imaging of the zebrafish left-right organizer (Kupffer's vesicle) combined with fluid dynamics calculations allows to quantitatively test the possible flow detection mechanisms and supports the flow transport of chemical signals as the mechanism of side determination.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al.
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    1. Cell Biology

    IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium

    Jenna L Wingfield et al.
    Multimegadalton intraflagellar transport (IFT) trains assemble by sequential recruitment of IFT subcomplexes from the cell body to the ciliary basal bodies and tubulin, the main IFT cargo, is loaded briefly before trains depart.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development

    Marisa Connell et al.
    HMMR regulates spindle positioning in neural and other cell types downstream of PLK1 and subsequently affects cortical NuMA-Dynein localization.
    1. Neuroscience

    Analysis of the NK2 homeobox gene ceh-24 reveals sublateral motor neuron control of left-right turning during sleep

    Juliane Schwarz, Henrik Bringmann
    A genetic analysis has identified the cholinergic SIA sublateral motor neurons, which innervate all four body wall muscles separately, as crucial regulators of turning around during sleep in Caenorhabditis elegans.

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