The apical polarity protein CRB3 is crucial for regulating vesicle trafficking in γ-tubulin ring complex assembly during ciliogenesis and cilium-related Hedgehog and Wnt signaling pathways in tumorigenesis.
Björn Udo Klink, Eldar Zent ... Alfred Wittinghofer
Six BBS proteins form a core BBSome transport vehicle, which is sufficient for recognizing membrane proteins for transport into the ciliary compartment.
Serial-section EM analysis uncovers the CNS connectome of a Ciona larva, the second of any entire nervous system, and exposes left-right asymmetries in its synaptic circuits.
Laura Vuolo, Nicola L Stevenson ... David J Stephens
Genetic knock-outs of the dynein-2 intermediate chains reveals that both are essential for correct cilia function and transition zone organization, but play different functions in the assembly of dynein-2 motor and in primary cilia formation.
Inna V Nechipurenko, Cristina Berciu ... Daniela Nicastro
Building on previous work (Doroquez et al., 2014), it is shown that the centriole core of the basal body degenerates, but the outer wall remodels to template the ciliary axoneme in a subset of C. elegans ciliated sensory neurons.
During cilium-generated signaling, ciliary membrane protein trafficking is unidirectional and ciliary membrane protein composition is regulated through action in the cytoplasm of the retrograde intraflagelllar transport (IFT) motor and shedding of ciliary ectosomes.
Cayla E Jewett, Bailey L McCurdy ... Chad G Pearson
Trisomy 21, the genetic cause of Down syndrome, produces elevated centrosome protein levels reducing intracellular trafficking to and from the centrosome thereby delaying primary ciliogenesis, ciliary signaling, and mouse cerebellar development.
Dhivya Kumar, Daniela Strenkert ... Betty A Eipper
Analysis of Chlamydomonas, planaria and mice reveals a novel and unanticipated role for a peptide amidating enzyme in primary and motile ciliary assembly through effects on post-Golgi trafficking.
