904 results found
    1. Ecology
    2. Evolutionary Biology

    Wide-ranging consequences of priority effects governed by an overarching factor

    Callie R Chappell, Manpreet K Dhami ... Tadashi Fukami
    Analysis of microbial communities in floral nectar shows that it is possible to identify an overarching factor that governs the eco-evolutionary dynamics of priority effects across multiple levels of biological organization.
    1. Developmental Biology
    2. Neuroscience

    The cellular basis of mechanosensory Merkel-cell innervation during development

    Blair A Jenkins, Natalia M Fontecilla ... Ellen A Lumpkin
    Touch-sensitive neurons are patterned during mammalian skin development by placode-derived keratinocytes and Bone Morphogenetic Protein signaling.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A bacterial membrane sculpting protein with BAR domain-like activity

    Daniel A Phillips, Lori A Zacharoff ... Sarah M Glaven
    Uniform diameter and curvature of the outer membrane extensions and vesicles of Shewanella oneidensis are maintained by a bacterial Bin/Amphiphysin/Rvs (BAR) domain-like protein BdpA.
    1. Neuroscience

    The signaling lipid sphingosine 1-phosphate regulates mechanical pain

    Rose Z Hill, Benjamin U Hoffman ... Diana M Bautista
    Constitutive sphingosine 1-phosphate signaling via the G-protein coupled receptor S1PR3 in mechanonociceptive somatosensory neurons is required for normal behavioral responses to noxious mechanical stimuli.
    1. Neuroscience

    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

    Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon, Sarah E Lower ... Jing-Ke Weng
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Cell Biology
    2. Neuroscience

    Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s Disease

    Vibhavari Aysha Bansal, Jia Min Tan ... Toh Hean Ch’ng
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    Strategically managing learning during perceptual decision making

    Javier Masís, Travis Chapman ... Andrew M Saxe
    During perceptual decision making, maximizing total reward in the long term requires trading reward in the short term for a faster improvement in perceptual representations.
    1. Evolutionary Biology

    Palatal morphology predicts the paleobiology of early salamanders

    Jia Jia, Guangzhao Li, Ke-Qin Gao
    Salamanders originate as metamorphosed with a biphasic lifestyle as shown by the palate shape and several non-shape features associated with the vomerine teeth, with diverse ecological types displayed in living species achieved in the Early Cretaceous.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation

    Hayden AM Hatch, Helen M Belalcazar ... Julie Secombe
    The histone demethylase KDM5 functions in concert with the transcription factor Prospero to regulate a gene expression program that is required for mushroom body neuroanatomical development.

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