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    1. Neuroscience

    Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing

    Colin M Cleary, Brenda M Milla ... Daniel K Mulkey
    Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO2/H+-dependent disinhibition.
    1. Cell Biology
    2. Developmental Biology

    LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

    Laura Bozal-Basterra, María Gonzalez-Santamarta ... Rosa Barrio
    LUZP1 is required for proper cilia and cytoskeleton formation.
    1. Cell Biology

    Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

    Fan Ye, David K Breslow ... Maxence V Nachury
    Membrane receptor proteins move through primary cilia largely by passive diffusion rather than by active intraflagellar transport.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans

    David B Doroquez, Cristina Berciu ... Daniela Nicastro
    The three-dimensional structures of 50 sensory cilia present in the head of the adult C. elegans hermaphrodite have been reconstructed to provide a foundation for investigations into the mechanisms by which the diversity of cilia structures is generated and how this structural diversity is related to specific sensory neuron functions.
    1. Neuroscience

    Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva

    Csaba Verasztó, Nobuo Ueda ... Gáspár Jékely
    Connectomic reconstruction combined with activity imaging uncovered a rhythmically active neuronal circuit for the coordination of ciliary activity across the whole body of a marine larva.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration

    Amanda M Travis, Samiya Manocha ... Jillian N Pearring
    Dominant mutations in Arl3, linked to inherited retinal dystrophy, disrupt the active Arl3-GTP ciliary gradient and cause a defect in rod photoreceptor nuclear migration that can be rescued by elevating ciliary Arl3 activity or reducing aberrant non-ciliary Arl3 activity.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates

    Hiroshi Yamaguchi, Motohiro Morikawa, Masahide Kikkawa
    Zebrafish genetics and sperm cryo-electron tomography reveal a novel function of Calaxin as a docking complex component stabilizing the outer arm dynein onto the ciliary doublet microtubule.
    1. Cell Biology
    2. Developmental Biology

    Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila

    Jean-André Lapart, Marco Gottardo ... Bénédicte Durand
    Genetic analyses in Drosophila establish the functional hierarchy of the ciliary transition zone module, Dzip1/Fam92/Cby, and reveal tissue specific variations in basal body anchoring pathways in fly ciliated tissues.
    1. Developmental Biology

    T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

    Uchenna Emechebe, Pavan Kumar P ... Anne M Moon
    The transcription and splicing factor T-box3 is present in primary cilia, regulates multiple aspects of limb development, and interacts with members of the protein complex required for the stability and processing of the Gli3 transcription factor.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

    Janani Gopalan, Mitchell H Omar ... John D Scott
    An anchored phosphatase-deacetylase complex participates in primary cilia development.