22 results found
    1. Structural Biology and Molecular Biophysics

    Structure of the human BBSome core complex

    Björn Udo Klink et al.
    The structure of the human BBSome explains how the subunits interact with each other and how disease-causing mutations hamper this interaction.
    1. Cell Biology

    Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

    Laura Vuolo et al.
    Genetic knock-outs of the dynein-2 intermediate chains reveals that both are essential for correct cilia function and transition zone organization, but play different functions in the assembly of dynein-2 motor and in primary cilia formation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A recombinant BBSome core complex and how it interacts with ciliary cargo

    Björn Udo Klink et al.
    Six BBS proteins form a core BBSome transport vehicle, which is sufficient for recognizing membrane proteins for transport into the ciliary compartment.
    1. Developmental Biology

    Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

    Céline Portal et al.
    Primary cilia of neural crest-derived cells mediate Indian hedgehog-induced signal transduction in the periocular mesenchyme and are required for normal anterior segment development.
    1. Cell Biology

    The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport

    Diego Huet et al.
    A small GTPase within the flagellum can participate in the control of transport from the base to the tip of the flagellum, and back again.
    1. Cell Biology
    2. Neuroscience

    TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons

    Emily Bowie, Sarah C Goetz
    Signaling at the primary cilium is important to sustain the morphology, connectivity, and survival of a key neural population within the brain.
    1. Cell Biology

    Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism

    Sam Li et al.
    A detailed description of the structure of procentriole MT triplet by cryoET, along with its associated non-tubulin proteins and its assembly intermediates, reveals possible molecular mechanism for the procentriole assembly.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

    Katja Gotthardt et al.
    The ciliary G-protein Arl13B – which is often mutated in Joubert syndrome – is the Guanine nucleotide exchange factor for the G-protein Arl3 and exclusively localizes to cilia.
    1. Cell Biology

    The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium

    Weiping Wang et al.
    The anaphase promoting complex (APC) has an essential role in ubiquitin-mediated proteolysis in the disassembly of cilia.
    1. Cell Biology
    2. Developmental Biology

    Coordinated genomic control of ciliogenesis and cell movement by RFX2

    Mei-I Chung et al.
    Systems-level analysis in vertebrate ciliated epithelial cells shows that the network of genes activated by the transcription factor Rfx2 controls the development, migration, insertion and function of these cells.

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