Behavioral, pharmacological, optogenetic, electrophysiological and computational analyses suggest that the anterior dorsal striatum is a causal node in the network responsible for evidence accumulation.
The dorsolateral prefrontal cortex integrates concurrent externally and internally generated predictions of task demand to guide information processing, while the medial prefrontal cortex corrects its prediction error based on actual task demand.
The BB model explains spatial cognition in terms of interactions between specific neuronal populations, providing a common computational framework for the human neuropsychological and in vivo animal electrophysiological literatures.
The alpha-synuclein fibril structure reported here buries residues 50-57 at the interface between its two protofilaments, suggesting that familial Parkinson's disease associated mutations in these residues lead to a structure not compatible with the one presented here.
High-frequency stimulation of the upper thoracic spinal cord corrects anticipatory postural adjustments and improving gait efficiency and inhibiting freezing of gait episodes in advanced Parkinson's disease.