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    1. Neuroscience

    Misaligned feeding impairs memories

    Dawn H Loh et al.
    The time at which mice consume food can dramatically affect hippocampal-dependent biochemistry, physiology, and learned behavior.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

    Jerome S Menet et al.
    Genome-wide measurements on mouse liver cells show that transcription, and a particular key transcription factor, have a smaller than expected influence on the mouse circadian system.
    1. Human Biology and Medicine
    2. Neuroscience

    A Cryptochrome 2 mutation yields advanced sleep phase in humans

    Arisa Hirano et al.
    A missense mutation in the human Cryptochrome 2 (CRY2) gene leads to the condition of familial advanced sleep phase.
    1. Genetics and Genomics
    2. Neuroscience

    Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue

    Renske Erion et al.
    Neuropeptide F/Y from neurons drives rhythmic expression of detoxification-related genes in a peripheral metabolic tissue in flies and mice.
    1. Structural Biology and Molecular Biophysics

    Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex

    Shannon N Nangle et al.
    X-ray crystallography reveals the structural framework for understanding the function of mammalian transcriptional repression in the cellular circadian clock.
    1. Plant Biology

    Accurate timekeeping is controlled by a cycling activator in Arabidopsis

    Polly Yingshan Hsu et al.
    The circadian clock in the model plant organism Arabidopsis thaliana is best described as a highly connected network made up of clock-regulated activators and repressors of transcription, rather than two coupled, repressor-based feedback loops.
    1. Plant Biology

    PCH1 integrates circadian and light-signaling pathways to control photoperiod-responsive growth in Arabidopsis

    He Huang et al.
    A conserved, circadian-regulated protein alters light perception in plants to regulate daily growth in response to changing photoperiod.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Switching of metabolic programs in response to light availability is an essential function of the cyanobacterial circadian output pathway

    Anna M Puszynska, Erin K O'Shea
    The circadian clock of Synechococcus elongatus PCC7942 schedules the activity of the transcription factor RpaA, which controls key events in carbon metabolism that contribute to cell fitness in conditions mimicking the natural environment.
    1. Human Biology and Medicine
    2. Neuroscience

    Rai1 frees mice from the repression of active wake behaviors by light

    Shanaz Diessler et al.
    Halving dosage of the Smith-Magenis syndrome responsible gene Rai1 in the mouse greatly amplifies the direct, suppressing effects of light on active-wake behavior through increased activation of the ventral-subparaventricular zone.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Circadian RNA expression elicited by 3’-UTR IRAlu-paraspeckle associated elements

    Manon Torres et al.
    Circadian gene expression can be driven by a post-transcriptional mechanism involving circadian mRNA nuclear retention by paraspeckle nuclear bodies.