2,042 results found
    1. Neuroscience

    Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

    Lynne Chantranupong et al.
    Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.
    1. Neuroscience

    Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior

    Igor Gridchyn et al.
    The optogenetic manipulation of hippocampal neuronal circuit activity revealed plastic changes of pyramidal-interneuron connections in behaving animals, which were primarily governed by the firing rate change of postsynaptic interneurons.
    1. Developmental Biology

    Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

    Yuto Yoshinari et al.
    Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.
    1. Cell Biology
    2. Neuroscience

    A feedback loop governs the relationship between lipid metabolism and longevity

    Nicole K Littlejohn et al.
    The dual control of adiposity and longevity emerges from a latent intestinal feedback loop which simultaneously augments fat loss and shields lifespan from the deleterious effects of continuous fat oxidation.
    1. Neuroscience

    Cannabinoids modulate associative cerebellar learning via alterations in behavioral state

    Catarina Albergaria et al.
    Cannabinoid receptors modulate cerebellar learning, not through direct effects on synaptic plasticity, but as a secondary consequence of their modulation of behavioral state.
    1. Neuroscience

    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

    Qin Wang et al.
    Precise spatiotemporal optogenetic activation of ERK and AKT signaling pathways reveals neural repair mechanisms of the peripheral and central nervous systems in live Drosophila larvae.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland et al.
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.
    1. Neuroscience

    Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture

    Claire S Oldfield et al.
    Experience strengthens hunting in larval zebrafish by recruiting the forebrain to increase the prey-evoked activity in visual areas and trigger motor activity and prey capture.

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