2,440 results found
    1. Immunology and Inflammation
    2. Neuroscience

    Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

    Kevin G Burfeind et al.
    Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
    1. Stem Cells and Regenerative Medicine

    Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

    Andrew W DeVilbiss et al.
    A method was developed for the metabolomic analysis of small numbers of flow cytometrically isolated cells from rare cell populations such as hematopoietic stem cells and circulating cancer cells.
    1. Cancer Biology

    Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer

    Kevin M Elias et al.
    Application of machine learning to serum miRNA profiles generated through next generation sequencing identifies a biologically relevant miRNA signature which can be deployed as a qPCR test to assist the diagnosis of epithelial ovarian cancer.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

    Amy W Ku et al.
    Tumor-induced myeloid-derived suppressor cells exert systemic suppression of adaptive immunity by limiting L-selectin-directed trafficking of T cells at vascular checkpoints in lymph nodes.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

    Mark R Sullivan et al.
    The nutrients available in some tumors and the factors that influence tumor nutrient availability are characterized, which provides insight into the metabolic constraints of the tumor microenvironment.
    1. Evolutionary Biology

    Group phenotypic composition in cancer

    Jean-Pascal Capp et al.
    Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
    1. Cancer Biology
    2. Immunology and Inflammation

    The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

    Alison Caldwell et al.
    A recently discovered contagious cancer in the Tasmanian devil has the potential to become widespread in the population due to the loss of histocompatibility antigens that are allogeneic to its hosts.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

    Helene Rundqvist et al.
    Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.
    1. Computational and Systems Biology
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    Meta-Research: Releasing a preprint is associated with more attention and citations for the peer-reviewed article

    Darwin Y Fu, Jacob J Hughey
    An analysis of more than 70,000 journal articles, including 5405 that were first released as a preprint on bioRxiv, shows that articles with a preprint received 49% more attention and 36% more citations than articles without one.
    1. Cancer Biology

    KRAS-dependent sorting of miRNA to exosomes

    Diana J Cha et al.
    In isogenically matched colorectal cancer (CRC) cell lines, mutant KRAS alters the composition of secreted miRNAs in extracellular vesicles that can then transfer repressive activity to wild type cells.

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