319 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Bacterial cell cycle control by citrate synthase independent of enzymatic activity

    Matthieu Bergé et al.
    A key enzyme of central energy metabolism, citrate synthase, regulates bacterial cell cycle progression at a very specific stage (S-phase) and independently of its enzymatic activity.
    1. Evolutionary Biology

    Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

    Erik M Quandt et al.
    A long-term evolution experiment with Escherichia coli shows that the appearance and optimization of a new trait can require both co-opting existing cellular pathways for new roles and reversing a history of previous adaptation.
    1. Ecology
    2. Evolutionary Biology

    Thermal acclimation of tropical coral reef fishes to global heat waves

    Jacob L Johansen et al.
    The ability of animals to adjust to thermal stress is critical for survival under global warming, yet the adjustment process and scope have (until now) remained obscure in marine fishes.
    1. Microbiology and Infectious Disease

    NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli

    Loïc Léger et al.
    Genetic and biochemical approaches uncover a novel mode of regulation of the alarmone synthetase RelA through a functional and direct interaction with the small subunit of the nitrite reductase NirD.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Identification of cryptic subunits from an apicomplexan ATP synthase

    Diego Huet et al.
    A phylum-specific ATP synthase subunit is needed for proper mitochondrial function and stability of the complex in Toxoplasma gondii.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergy between the small intrinsically disordered protein Hsp12 and trehalose sustain viability after severe desiccation

    Skylar Xantus Kim et al.
    Two small, energy independent stress effectors are able to counteract all of the major insults imposed by severe water loss.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans

    Donato Giovannelli et al.
    The genome of Thermovibrio ammonificans encodes ancestral pathways (e.g., hydrogen oxidation) and more recently acquired ones (e.g., nitrate reduction) and a hybrid pathway for CO2 fixation.
    1. Structural Biology and Molecular Biophysics

    A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins

    Danish Khan et al.
    A new class of fungal hemoproteins is described that emphasizes the versatility of the Sec14-fold for translating binding of chemically distinct ligands to control of diverse sets of cellular activities.
    1. Cancer Biology
    2. Developmental Biology

    A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion

    Katarina Valoskova et al.
    T antigen glycosylation, which marks metastatic cancer cells, is modulated on a small set of proteins by a conserved multipass transmembrane protein to allow tissue invasion by Drosophila macrophages.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins

    Agnes Ulfig et al.
    N-chlorination, a reversible, oxidative modification, turns plasma proteins into holdase-like chaperones, potent activators of immune cells and pro-survival factors for phagocytic immune cells.

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