1,505 results found
    1. Neuroscience

    Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

    Alexander L Markowitz, Radha Kalluri
    The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
    1. Biochemistry and Chemical Biology

    Stepwise assembly of the human replicative polymerase holoenzyme

    Mark Hedglin et al.
    Fluorescence resonance energy transfer has been used to explore the interactions between DNA polymerases, sliding clamps and clamp loaders as DNA is replicated in human cells.
    1. Chromosomes and Gene Expression

    The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast

    Sanjeeta Tamang et al.
    Unloading the polymerase sliding clamp PCNA from DNA by Elg1 promotes recombination at the RTS1 replication fork barrier by limiting Fbh1 and Srs2 activity.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Epidemiology: Promiscuous bacteria have staying power

    Ruth C Massey, Daniel J Wilson
    Being able to take up DNA from their environment might allow pneumococcal bacteria to colonize the human nose and throat for longer periods of time.
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    1. Ecology
    2. Evolutionary Biology
    Zebrafish illustration

    The Natural History of Model Organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution

    David M Parichy
    The zebrafish is a premier model organism for biomedical research, with a rich array of tools and genomic resources, and combining these with a fuller appreciation of wild zebrafish ecology could greatly extend its utility in biological research.
  1. Point of View: Hidden value

    Brooke Morriswood, Oliver Hoeller
    The fact that it is difficult to evaluate and compare the outputs of individual researchers might actually be good for science.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Paleoproteomics: Proteins from the past

    Adam F Wallace, James D Schiffbauer
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    1. Neuroscience

    Motor Control: A choice motif

    Sabine L Renninger, Michael B Orger
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  2. Peer Review: The pleasure of publishing

    Vivek Malhotra, Eve Marder
    When assessing manuscripts eLife editors look for a combination of rigour and insight, along with results and ideas that make other researchers think differently about their subject.
    Editorial
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    1. Neuroscience

    Sensory Neurons: A new target for G protein signaling

    László Csanády
    G protein-coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gβγ subunit to the channel.
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