478 results found
    1. Cell Biology

    BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

    Chang Zhang et al.
    BLOS1 is a new regulator of LDLR endosomal recycling through coordinating kinesins during long-range transport, and depletion of BLOS1 in mouse liver leads to aberrant lipid metabolism.
    1. Neuroscience

    Extended field-of-view ultrathin microendoscopes for high-resolution two-photon imaging with minimal invasiveness

    Andrea Antonini et al.
    Aberration correction using 3D microprinting in ultrathin microendoscopes allows two-photon imaging of large neuronal networks with homogeneously high spatial resolution and minimal invasiveness in the deep mouse brain.
    1. Immunology and Inflammation

    LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

    Jack P Green et al.
    Depletion of LRRC8A provides genetic evidence for the importance of Cl- channels in NLRP3 activation.
    1. Cell Biology
    2. Immunology and Inflammation

    Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

    Elizabeth Rivers et al.
    WASp is an immunometabolic regulator of human myeloid cells and regulates autophagy and mitochondrial homeostasis.
    1. Chromosomes and Gene Expression

    Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm7 complex

    Yulia Vasianovich et al.
    A new tool that allows specific subpopulations of telomerase RNAs in vivo forces a thorough revision of the telomerase maturation pathway and suggests a new function for Mex67.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity

    Mark Shaaya et al.
    Light-sensitive allosteric switch module, a broadly applicable protein engineering method, is used for the regulation of protein activity with tight temporal control and spatial precision.
    1. Cell Biology

    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

    Ashutosh Kumar et al.
    LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
    1. Biochemistry and Chemical Biology

    Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

    Deepti Karandur et al.
    Activation and autophosphorylation of CaMKII releases the regulatory segment, which can then bind to and destabilize the hub assembly by trapping large fluctuations in the hub architecture.
    1. Computational and Systems Biology
    2. Developmental Biology

    Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

    Sumeda Nandadasa et al.
    Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein

    Mikel Garcia-Marcos et al.
    LOV2GIVe allows to activate Gi proteins non-invasively with innocuous blue light based on a design principle unrelated to light-activated GPCRs (metazoan opsins), thereby expanding the range of potential experimental applications.

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