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Large-scale multi-omics analysis of genomic high-occupancy target regions in humans suggests involvement of large transcriptional condensates.

The transcriptional adapter protein NCOR1 that links chromatin-modifying enzymes with gene-specific transcription factors controls naive and effector regulatory T cell states.

PTEN mutations disrupt inhibitory GABAergic signaling, causing neurodevelopmental defects that can be mitigated by β-hydroxybutyrate, which activates DAF-16/FOXO and may offer a therapeutic approach for excitation/inhibition imbalances.

Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.

The Pseudomonas aeruginosa secreted signaling molecule 2'-aminoacetophenone modulates cellular immunometabolism to promote persistence in infected tissues.