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    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain

    Claudia Scheckel et al.
    Neuronal ELAV-like (nELAVL) proteins are associated with non-coding Y RNAs in stressed neurons and in the brains of Alzheimer's disease patients, suggesting a new means of regulatory protein sequestration and mRNA target regulation.
    1. Neuroscience

    Patterned perturbation of inhibition can reveal the dynamical structure of neural processing

    Sadra Sadeh, Claudia Clopath
    Neuronal networks with strong functional specificity of connections between excitatory and inhibitory neurons show specific dynamics of inhibitory stabilization, accompanied with rapid spontaneous activity transitions between highly selective functional states.
    1. Cell Biology
    2. Developmental Biology

    Drosophila non-muscle myosin II motor activity determines the rate of tissue folding

    Claudia G Vasquez et al.
    The rate of cell and tissue contraction scales with the motor activity of myosin 2.
    1. Structural Biology and Molecular Biophysics

    Large-scale state-dependent membrane remodeling by a transporter protein

    Wenchang Zhou et al.
    The conformational mechanism of a transporter protein is found to have profound and energetically costly effects on the morphology of the surrounding membrane.
    1. Chromosomes and Gene Expression

    Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis

    Christina Ernst et al.
    Transmission of an entire human chromosome through the mouse male germline reveals an unexpectedly high tolerance of aneuploidy during male meiosis and results in accurate transcriptional deployment despite massive epigenetic remodeling during spermatogenesis.
    1. Developmental Biology
    2. Neuroscience

    TIAM-1/GEF can shape somatosensory dendrites independently of its GEF activity by regulating F-actin localization

    Leo TH Tang et al.
    The DMA-1/LRR-TM cell surface receptor signals through partially redundant pathways to cell-autonomously pattern dendrites, including by directly forming a complex with both the TIAM-1/GEF and ACT-4/Actin.
    1. Cell Biology
    2. Genetics and Genomics

    Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

    Fabrizio Orsenigo et al.
    Single-cell RNA analysis of brain endothelium identifies the angiogenic venous capillary subset and respective resident endothelial progenitors at the origin of CCM lesions, while arterial endothelial cells are unaffected.
    1. Cell Biology
    2. Developmental Biology

    Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

    Joana R Carvalho et al.
    Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
    1. Evolutionary Biology

    Telomeres: Change and HOAP for the best

    Claudia Castillo-González, Dorothy E Shippen
    HOAP is a telomere-binding protein that has a conserved role in Drosophila, but it also needs to evolve quickly to restrict telomeric retrotransposons.
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