773 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An analog to digital converter controls bistable transfer competence development of a widespread bacterial integrative and conjugative element

    Nicolas Carraro et al.
    A new multistep hierarchical cascade controls activation of an integrative and conjugative element in a small subpopulation of cells in its bacterial host, yielding proficient DNA transferring cells.
    1. Cancer Biology
    2. Genetics and Genomics

    Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes

    Stevephen Hung et al.
    Non-coding mutations in microsatellite-instable (MSI) colorectal tumors are prevalent and activate cancer-specific enhancers, thereby disrupting gene expression control.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

    Ethan V Abel et al.
    HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.
    1. Computational and Systems Biology

    A decentralised neural model explaining optimal integration of navigational strategies in insects

    Xuelong Sun et al.
    The first biology-constrained neural model of insect navigation guidance systems was explained including path integration, visual homing and route following, and their optimal coordination.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the disaggregase activity and regulation of Hsp104

    Alexander Heuck et al.
    Protein disaggregases employ two mechanically-linked ATPase rings that are under steric control by a wrapped-around coiled-coil belt.
    1. Cell Biology

    The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis

    Donglei Zhang, Michael Glotzer
    Activation of the key regulator of cytokinesis, RhoA, involves an unexpected contribution by a RhoGAP domain.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

    Gernot Wolf et al.
    Unbiased ChIP-seq screens and genetic knockouts of large Kruppel associated box zinc finger protein (KRAB-ZFP) clusters reveal that evolutionarily young KRAB-ZFPs play a redundant role in retrotransposon restriction in mice.
    1. Developmental Biology
    2. Neuroscience

    Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1

    Hsin-I Jen et al.
    The mammalian utricle can better regenerate hair cells compared to the cochlea because it maintains hair cell gene loci in a more transcriptionally accessible state.
    1. Computational and Systems Biology
    2. Neuroscience

    Automated analysis of long-term grooming behavior in Drosophila using a k-nearest neighbors classifier

    Bing Qiao et al.
    Drosophila grooming is driven by two internal programs.
    1. Chromosomes and Gene Expression

    Translation affects mRNA stability in a codon-dependent manner in human cells

    Qiushuang Wu et al.
    Genomic-profiles and reporters reveal that the three-nucleotide ‘words’ read by the ribosome, codons, have a strong effect on mRNA stability, impacting the homeostatic mRNA and protein levels in human cells.

Refine your results by:

Type
Research categories