175 results found
    1. Neuroscience

    Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity

    Angela K Nietz et al.
    Climbing fiber glutamate spillover enhances response complexity and regulates signaling to Golgi cells through a form of transmission not constrained to synapses.
    1. Neuroscience

    AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae

    Mohini Sengupta, Vatsala Thirumalai
    In vivo recordings in unanesthetized zebrafish larvae show that Purkinje neurons have two stable membrane potential states and that climbing fiber inputs can toggle them to up states during motor episodes.
    1. Neuroscience

    Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning

    Yan Yang, Stephen G Lisberger
    During learning, one climbing fiber input instructs plasticity that is expressed in the simple-spike responses of cerebellar Purkinje cells, and causes neural learning that may inhibit future climbing fiber instructions.
    1. Neuroscience

    Gating of neural error signals during motor learning

    Rhea R Kimpo et al.
    Electrode recordings and optogenetics reveal that the cerebellum can modulate its response to error signals from the brainstem during motor learning.
    1. Neuroscience

    Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice

    Farzaneh Najafi et al.
    Sensory-driven calcium spikes in Purkinje cells are not binary; instead, they are graded and can provide information about the strength of a periocular airpuff stimulus known to drive learning.
    1. Neuroscience

    Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements

    Michael A Gaffield et al.
    In behaving mice, inhibition from molecular layer interneurons attenuates excitation of Purkinje cells by parallel fibers and suppresses their ability to enhance climbing fiber-triggered dendritic Ca2+ responses.
    1. Neuroscience

    Neuroscience: Multitasking on the run

    Mary E Hatten, Stephen G Lisberger
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    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

    Fahad Rashid et al.
    Structure specific nucleases that act in DNA replication, repair and recombination actively mold their DNA while transforming their own structure to achieve precise cleavage of their cognate DNA and avoid the deleterious cleavage of noncognate DNA.
    1. Neuroscience

    Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice

    Shu-Hsien Sheu et al.
    A similar pattern of developmental synaptic refinement leads two consecutive synaptic relays to have the same organization suggesting that some general principle of neural organization is at play.

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