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    1. Neuroscience

    Dendritic coincidence detection in Purkinje neurons of awake mice

    Christopher J Roome, Bernd Kuhn
    Simultaneous voltage and calcium two-photon imaging of Purkinje neuron dendrites in awake mice reveals multiple interplaying mechanisms underlying sensory-evoked dendritic coincidence detection of parallel fiber and climbing fiber input.
    1. Neuroscience

    Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements

    Michael A Gaffield et al.
    In behaving mice, inhibition from molecular layer interneurons attenuates excitation of Purkinje cells by parallel fibers and suppresses their ability to enhance climbing fiber-triggered dendritic Ca2+ responses.
    1. Neuroscience

    Neuroscience: Multitasking on the run

    Mary E Hatten, Stephen G Lisberger
    Insight
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    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Neuroscience

    Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

    Alexander L Markowitz, Radha Kalluri
    The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
    1. Genetics and Genomics
    2. Neuroscience

    Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons

    Kenichi Ishii et al.
    Sex-specific characteristics of the fruit fly courtship behavior are not specified by a single binary switch, but as a combination of traits that are modularly specified by separable genetic switches.
    1. Neuroscience

    Principles of operation of a cerebellar learning circuit

    David J Herzfeld et al.
    Quantitative analysis of behavior coupled with computational modeling reveal the set of circuit-level principles that underlie cerebellar-dependent motor learning in smooth pursuit eye movements of monkeys across timescales.
    1. Genetics and Genomics
    2. Neuroscience

    Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophila

    Margot Wohl et al.
    Male-type aggressive and courtship behaviors of the fruit flies are differentially specified by two sex-determining genes, providing a substrate for the evolution to sculpt these two behaviors independently.
    1. Neuroscience

    Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data

    Samuel A Neymotin et al.
    Human Neocortical Neurosolver is a new user-friendly software tool for researchers to develop and test hypotheses on cellular/circuit origins of human MEG/EEG signals using a biophysical model.
    1. Medicine

    The tricuspid valve also maladapts as shown in sheep with biventricular heart failure

    William D Meador et al.
    Demonstrating the tricuspid valve maladapts is critical, and understanding its regurgitation may aid in developing better treatment strategies.