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    1. Cell Biology
    2. Neuroscience

    Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction

    Qi Wang et al.
    Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.
    1. Epidemiology and Global Health
    2. Medicine

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay et al.
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

    Caitlin N Spaulding et al.
    The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
    1. Chromosomes and Gene Expression

    The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress

    Takeshi Wakida et al.
    Minimizing anti-proliferation signaling from DNA damage detection machinery is the tactic for the cells to drive proliferation under genotoxic environment, and the function is exerted by Polo-Like-Kinase1 that is frequently over-expressed in cancer cells.
    1. Neuroscience

    Cerebellar learning using perturbations

    Guy Bouvier et al.
    A proposal for a complete cellular/network implementation of trial-and-error motor learning in the olivo-cerebellar system.
    1. Neuroscience

    Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours

    Laura D Knogler et al.
    Purkinje cells of the cerebellum, a conserved vertebrate brain region important for sensorimotor integration, receive sensory and motor information from distinct input streams and are functionally clustered into modules reflecting the larval zebrafish's behavioral repertoire.
    1. Neuroscience

    Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance

    Luis A Bezares-Calderón et al.
    The Platynereis startle circuit links polycystin-dependent hydrodynamic sensors to muscle and ciliary effector cells.
    1. Neuroscience

    Multiplexed coding by cerebellar Purkinje neurons

    Sungho Hong et al.
    Cerebellar Purkinje neurons use a multiplexed simple spike code combining synchrony/spike time and firing rate, with each component encoding distinct information about movements such as motion onset timing and kinematics.
    1. Neuroscience

    Multimodal sensory integration in single cerebellar granule cells in vivo

    Taro Ishikawa et al.
    Building on previous work (Huang et al., 2013), it is shown that single granule cells receive excitatory synaptic input driven by up to three separate sensory modalities in vivo, which demonstrate that individual neurons can contribute to multisensory integration at the input layer of the cerebellar cortex.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

    Fahad Rashid et al.
    Structure specific nucleases that act in DNA replication, repair and recombination actively mold their DNA while transforming their own structure to achieve precise cleavage of their cognate DNA and avoid the deleterious cleavage of noncognate DNA.