In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.
ATG9-dependent autophagy is an essential pathway for long-term survival within the cyst in the parasite Toxoplasma gondii and could be exploited in future studies seeking interventions against persistent Toxoplasma infection.
The direct interaction of R-type Ca2+ channel Cav2.3 and GABAB receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABAB receptor activation.
Computational modeling, and empirical behavioral and EEG results show that learning relies not only on comparing current events to past experience, but integrates response-based outcome predictions and confidence.
Immunohistochemical labeling of antigens deep within mouse brain tissue sections was achieved without the need for lipid permeabilization, thereby preserving tissue ultrastructure and enabling correlative light and electron microscopy studies.