2,285 results found
    1. Structural Biology and Molecular Biophysics

    Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

    Zhijie Lin et al.
    A systematic and quantitative investigation showing how highly specific WW domain-mediated protein-protein interaction network is organized in cell growth and polarity.
    1. Developmental Biology
    2. Neuroscience

    Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb

    Luis Sánchez-Guardado, Carlos Lois
    Sister projection neurons in the mammalian olfactory system do not share sensory synaptic input indicating that lineage-independent mechanisms regulate their synaptic connectivity with the olfactory sensory neurons.
    1. Structural Biology and Molecular Biophysics

    High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

    Zhijie Chen et al.
    Direct observation of RNA Polymerase II transcription through a single nucleosome at near basepair resolution suggests a mechanism for selective control of gene expression.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends

    Taylor A Reid et al.
    EB1 targeting to growing microtubule plus-ends is facilitated by tapered microtubule tip structures.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

    Edward A Partlow et al.
    Cryo-EM reveals how a protein called NECAP inactivates the AP2 clathrin adaptor complex through concerted engagement of two domains which confer specificity for membrane-activated and phosphorylated AP2.
    1. Neuroscience

    Representational untangling by the firing rate nonlinearity in V1 simple cells

    Merse E Gáspár et al.
    Firing rate nonlinearity recovers linear decodability of orientation information from simple cells of the primary visual cortex under uncertainty of nuisance parameters phase and spatial frequency.
    1. Microbiology and Infectious Disease

    Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

    Kevin J Forsberg et al.
    A high-throughput, activity-based selection identifies many phage-derived inhibitors of Cas9 from human fecal and oral metagenomes, with at least one inhibitor acting via a novel mechanism.
    1. Neuroscience

    Spatial Navigation: A question of scale

    Muireann Irish, Siddharth Ramanan
    An fMRI experiment reveals distinct brain regions that respond in a graded manner as humans process distance information across increasing spatial scales.
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    1. Neuroscience

    Processing of different spatial scales in the human brain

    Michael Peer et al.
    When subjects perform spatial judgments in environments of increasing scale, brain activity shifts along posterior-anterior gradients, advancing from the visual system to the default-mode network.
    1. Developmental Biology

    Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish

    Craig T Jacobs, Peng Huang
    Genetic analyses combining photoconvertible cell signalling reporters with gain- and loss-of function manipulations reveal a novel role for Notch signalling in controlling Hedgehog response in neural progenitor cells.

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