8,623 results found
    1. Neuroscience

    Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion

    Steven Knafo, Kevin Fidelin ... Claire Wyart
    Bioluminescence monitoring and selective silencing in zebrafish larva reveal a novel sensorimotor circuit modulating speed in the moving spinal cord.
    1. Neuroscience

    Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

    Harshvardhan Gazula, Henry FJ Tregidgo ... Juan E Iglesias
    New open-source software enables, for the first time, extraction of quantitative information from brain dissection photographs that are routinely taken at brain banks for archiving purposes but otherwise not exploited.
    1. Structural Biology and Molecular Biophysics

    A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0

    Jasenko Zivanov, Joaquín Otón ... Sjors HW Scheres
    New functionality in RELION-4.0 allows convenient structure determination from cryo electron tomography data to resolutions sufficient for de novo atomic modelling.
    1. Immunology and Inflammation

    Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches

    Takuma Asahi, Shinya Abe ... Koichi Ikuta
    Interleukin 15-producing microenvironments in the fetal and adult liver foster a type 1 innate lymphoid cell lineage with intrinsic cytotoxicity mediated through cytotoxic granules that are expressed under their steady state, unlike conventional natural killer cells with stimulation-dependent cytotoxicity.
    1. Cell Biology

    Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

    Danielle B Buglak, Pauline Bougaran ... Victoria L Bautch
    The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function.
    1. Epidemiology and Global Health
    2. Medicine
    3. Cancer Biology

    Special Issue: The impact of the COVID-19 pandemic on cancer prevention, control, care and survivorship

    Edited by Eduardo Franco et al.
    Our latest Special Issue brings together research covering many different aspects of the impact of the COVID-19 pandemic on cancer outcomes across the globe.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Selfing is the safest sex for Caenorhabditis tropicalis

    Luke M Noble, John Yuen ... Matthew V Rockman
    Out breeding depression in Caenorhabditis tropicalis is due to common maternal-offspring incompatibilities that interact with a highly heterogeneous genetic background and may provide a short-term advantage to inbreeding.
    1. Structural Biology and Molecular Biophysics

    Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern

    Callum M Ives, Linh Nguyen ... Elisa Fadda
    Viral evolution can lead to mutations that render specific glycosylation sites dispensable for folding and for supporting the protein's function, allowing changes in the shield, and in the immunogenic profile.
    1. Neuroscience

    Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

    Lucas Schirmer, Wiebke Möbius ... David H Rowitch
    Ultrastructural and loss-of-function experiments show that oligodendrocyte-encoded Kir4.1 is located near active axonal structures, including within myelin inner tongue, and has critical functions to promote axonal activity and preserve integrity.
    1. Neuroscience

    Stepwise wiring of the Drosophila olfactory map requires specific Plexin B levels

    Jiefu Li, Ricardo Guajardo ... Liqun Luo
    PlexB plays a multifaceted role in instructing the assembly of the Drosophila olfactory circuit through temporally-regulated expression patterns and expression level-dependent effects.

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