As macrophages are involved in various aspects of non-small cell lung cancer development and progression it is crucial to develop appropriate 3D co-culture platforms for modeling immune cell-tumor cell interactions, leading to more efficacious macrophage-focused immunotherapies.

When pioneer metastatic cells enter a sentinel lymph node through afferent lymphatics subcapsular sinus, macrophages provide them soil to proliferate and colonize lymph node.

Novel brainstem organotypic cultures that generate rhythmic respiratory motor activity reveal the neural networks that control breathing and a new pathway in the hypercapnic response.

Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.

Novel high-throughput co-culture assays reveal how the spatial structure of colony biofilms provides opportunities for nutrient and matrix sharing and may drive the evolution of cooperative behaviors.

The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure.

Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.

Mutations conferring resistance to Escherichia coli against the chemotherapy drug gemcitabine can have opposite effects on bacterial drug degradation and therefore can increase or decrease the chemotherapy load on neighboring cancer cells.

The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.

Allowing aquatic organisms to grow in rice fields – a practice called co-culture – increases rice yields while maintaining soil fertility and reducing weeds.