5,112 results found
    1. Structural Biology and Molecular Biophysics

    Sequence co-evolution gives 3D contacts and structures of protein complexes

    Thomas A Hopf et al.
    Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Large-scale determination of previously unsolved protein structures using evolutionary information

    Sergey Ovchinnikov et al.
    A new method of protein structure prediction that incorporates residue–residue co-evolution information into the Rosetta structure prediction program was used to develop models for 58 large protein families that had no previous structural information.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway

    Bin Z He et al.
    The phosphate starvation response network in a commensal yeast evolved to expand its downstream targets via changes in the main transcription factor's dependence on its co-activator, potentially altering the physiological response.
    1. Microbiology and Infectious Disease

    Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis

    Vegard Eldholm et al.
    HIV co-infection does not affect Mycobacterium tuberculosis mutation rates and does not drive the emergence of antimicrobial resistance within patients in the largest outbreak of multidrug-resistant tuberculosis in Latin America to date.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Immune genes are hotspots of shared positive selection across birds and mammals

    Allison J Shultz, Timothy B Sackton
    Pathogens, particularly viruses, target the same genes over deep evolutionary time, resulting in shared signatures of positive selection and transcriptional responses at the same genes.
    1. Microbiology and Infectious Disease

    Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

    Melinda Ng et al.
    NPC1 is a genetic determinant of filovirus susceptibility in bats, and some variations in bat NPC1 may reflect host adaptations to reduce filovirus replication and virulence.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Assembling the Tat protein translocase

    Felicity Alcock et al.
    Evolutionary bioinformatics and experimentation are applied to the components of the Tat protein transport system to elucidate the structure of the membrane-bound receptor complex and to deduce a molecular description for its substrate-triggered activation.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway

    Steven W Miller et al.
    Hairless emerged as an evolutionarily novel regulatory protein that replaced an ancestral paradigm of direct co-repressor recruitment by Suppressor of Hairless, its partner transcription factor in the Notch signaling pathway.
    1. Developmental Biology

    Dynamic BMP signaling polarized by Toll patterns the dorsoventral axis in a hemimetabolous insect

    Lena Sachs et al.
    During the evolution of insect lineages, a signaling pathway dedicated to pathogen defense was co-opted for a new role in embryonic patterning.
    1. Evolutionary Biology

    Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

    Erik M Quandt et al.
    A long-term evolution experiment with Escherichia coli shows that the appearance and optimization of a new trait can require both co-opting existing cellular pathways for new roles and reversing a history of previous adaptation.

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