3,587 results found
    1. Plant Biology

    Plant–necrotroph co-transcriptome networks illuminate a metabolic battlefield

    Wei Zhang, Jason A Corwin ... Daniel J Kliebenstein
    Simultaneously measuring the transcriptomes of both a host plant and fungal pathogen, co-transcriptomics, identified diverse, dynamic and independent communication mechanisms conveying information between the two organisms via discrete gene modules.
    1. Cancer Biology
    2. Computational and Systems Biology

    Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

    Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
    Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics

    Emma M Briggs, Catarina A Marques ... Keith R Matthews
    Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.
    1. Cancer Biology
    2. Computational and Systems Biology

    Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

    Gökçe Senger, Stefano Santaguida, Martin H Schaefer
    Coordinated regulation of co-complex members compensates for aneuploidy-induced stoichiometric imbalances in human cancer.
    1. Cancer Biology

    Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis

    Rohit Singh, Beom K Choi
    When pioneer metastatic cells enter a sentinel lymph node through afferent lymphatics subcapsular sinus, macrophages provide them soil to proliferate and colonize lymph node.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival

    Matthew Tien, Aretha Fiebig, Sean Crosson
    A gene network analysis approach reveals a conserved small regulatory RNA that is crucial for bacterial cell survival across distinct stress conditions.
    1. Evolutionary Biology

    Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis

    Mayuko Hamada, Katja Schröder ... Thomas CG Bosch
    The symbiotic relationship between Hydra and Chlorella is driven by metabolic co-dependence and characterized by changes in the photobiont genome in terms of lack of genes essential in free-living algae.
    1. Cell Biology

    Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
    The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
    1. Cell Biology
    2. Developmental Biology

    Transcriptional drifts associated with environmental changes in endothelial cells

    Yalda Afshar, Feyiang Ma ... M Luisa Iruela-Arispe
    Nearly half of the transcriptome is altered when endothelial cells transition in vitro, expression patterns for some genes are regained by exposing cells to shear stress and others through exposure to smooth muscle cells.
    1. Developmental Biology
    2. Evolutionary Biology

    Gene age shapes the transcriptional landscape of sexual morphogenesis in mushroom-forming fungi (Agaricomycetes)

    Zsolt Merényi, Máté Virágh ... László G Nagy
    Allele-specific expression, natural antisense transcripts, and developmental gene expression, but not RNA editing or developmental hourglass, act in concert to shape the transcriptome during the fruiting body formation of complex multicellular fungi.

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