194 results found
    1. Ecology
    2. Evolutionary Biology

    Comparative genomics explains the evolutionary success of reef-forming corals

    Debashish Bhattacharya, Shobhit Agrawal ... Paul G Falkowski
    The analysis of 20 coral genomic datasets provides unprecedented insights into what makes reef-building corals unique, including the evolution of novel gene families involved in biomineralization, signaling and stress responses that have led to their evolutionary success throughout the Phanerozoic Eon.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    NF-κB oscillations translate into functionally related patterns of gene expression

    Samuel Zambrano, Ilario De Toma ... Alessandra Agresti
    NF-κB oscillations synchronize to external perturbations as a damped oscillator, producing different transcription dynamics.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Global donor and acceptor splicing site kinetics in human cells

    Leonhard Wachutka, Livia Caizzi ... Patrick Cramer
    Transient transcriptome sequencing and kinetic modeling suggest how the kinetics and yield of RNA splicing are encoded in the human genome.
    1. Developmental Biology

    Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

    Pengzhen Dong, Yue Li ... Hai Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Multifunctional requirements for ERK1/2 signaling in the development of ganglionic eminence derived glia and cortical inhibitory neurons

    Sara J. Knowles, Michael C. Holter ... Jason M. Newbern
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex

    J Daniel Obray, Erik T Wilkes ... L Judson Chandler
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology
    2. Genetics and Genomics

    Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth

    Ruby Oberin, Sigrid Petautschnig ... Patrick S Western
    Growth-delayed offspring generated from eggs that lacked normal epigenetic programming exhibited a remarkable capacity to undergo late gestational fetal growth recovery, despite inefficient placental function.
    1. Stem Cells and Regenerative Medicine

    Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

    Sujeethkumar Prithiviraj, Alejandro Garcia Garcia ... Paul E Bourgine
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Mixed representations of choice direction and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus

    Julianna Locantore, Yijun Liu ... Michael Wallace
    Basal ganglia output from the entopeduncular nucleus to the lateral habenula is not required for performance in a probabilistic switching task that requires flexible action/outcome decision making.
    1. Cell Biology
    2. Neuroscience

    Endocytic trafficking determines cellular tolerance of presynaptic opioid signaling

    Damien Jullié, Camila Benitez ... Mark von Zastrow
    Quantitative imaging of neurons reveals how opioid agonists produce long-term functional tolerance at presynaptic terminals through rapid internalization of receptors from the axonal surface.

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