4,360 results found
    1. Structural Biology and Molecular Biophysics

    Gating mechanisms during actin filament elongation by formins

    Fikret Aydin et al.
    Formins slow elongation of actin filament by either sterically blocking the addition of actin subunits or flattening the helical twist of the filament end.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Regulation of multispanning membrane protein topology via post-translational annealing

    Reid C Van Lehn et al.
    Coarse-grained modeling reveals a new mechanism for multispanning membrane protein topogenesis, in which misintegrated configurations of the proteins undergo post-translational annealing to reach final, fully integrated multispanning topologies.
    1. Computational and Systems Biology
    2. Neuroscience

    Biologically plausible learning in recurrent neural networks reproduces neural dynamics observed during cognitive tasks

    Thomas Miconi
    A biologically plausible learning rule allows recurrent neural networks to learn nontrivial tasks, using only sparse, delayed rewards, and the neural dynamics of trained networks exhibit complex dynamics observed in animal frontal cortices.
    1. Human Biology and Medicine

    Point of View: Competency-based assessment for the training of PhD students and early-career scientists

    Michael F Verderame et al.
    A method to assess the training of scientists, based on a set of 10 core competencies, is proposed.
  1. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
    1. Cell Biology
    2. Neuroscience

    2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics

    Sheena A Josselyn
    Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
    1. Stem Cells and Regenerative Medicine
    2. Human Biology and Medicine

    Organ Development: Tips from the embryonic lung

    Avinash Waghray, Jayaraj Rajagopal
    A new source of progenitor cells can now be used to study hidden aspects of human lung development and pediatric lung disease.
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  2. Peer Review: Rooting out bias

    Bridget M Kuehn
    Tackling unconscious bias is a major challenge for journals and the rest of the scientific community.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Point of View: Is cell size a spandrel?

    Ariel Amir
    Analysis of experiments on bacteria suggests that the dependence of cell size on growth rate is not an adaptation but a causal consequence of a regulatory mechanism that controls DNA replication.

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