Proximity proteomics combined with mouse genetics are used to assess the composition of active zone-like sites for dopamine release and reveal that the scaffolding protein RIM organizes these sites.
Cumulatively, from 1950 to 2015, smoking-related disease has been the biggest cause of premature death in high-income countries, with elevated risks of smoking continuing well into the 21st century.
The anticipation of rewards turns out to have its own hedonic value, on top of that of the reward itself; a wide range of behavioral and neurophysiological data suggest that this anticipation is boosted by prediction errors.
Methadone maintenance treatment (MMT) can alleviate opioid dependence, however, drivers receiving MMT were at high risk of motor vehicle collisions in the present study, particularly the first 90 days of MMT.
Alison M Luckey, Lauren S McLeod ... Sven Vanneste
Non-invasive transcutaneous electrical stimulation of the greater occipital nerve using direct current promotes strengthening of memories using late-phase synaptic activity.
Chronic inhibition of mTORC1 signaling strongly affects the morphology, physiology and output of dopamine neurons leading to impaired dopaminergic function in mice.
William Menegas, Joseph F Bergan ... Mitsuko Watabe-Uchida
Dopamine neurons projecting to different targets receive a similar set of inputs, rather than forming reciprocal connections, whereas those projecting to the posterior striatum receive a distinct set of inputs.
Artemis Koumoundourou, Märt Rannap ... Stefan Britsch
Molecular genetic, cell culture as well as electrophysiological analyses reveal a C1ql2/Neurexin3(25b+)-dependent molecular pathway through which Bcl11b controls critical functions of adult hippocampal mossy fiber synapses.
